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Smco2 Gene Detail
Summary
  • Symbol
    Smco2
  • Name
    single-pass membrane protein with coiled-coil domains 2
  • Synonyms
    1700023A16Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916621
    NCBI Gene: 69371
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:146751608-146772902 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 77.70 cM, cytoband G3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    395 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916621
 protein coding gene Chr6:146751602-146772904 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031492
 protein coding gene Chr6:151881491-151909137 (+)
A/J MGP_AJ_G0031467
 protein coding gene Chr6:145859379-145881790 (+)
AKR/J MGP_AKRJ_G0031395
 protein coding gene Chr6:150197906-150220534 (+)
BALB/cJ MGP_BALBcJ_G0031475
 protein coding gene Chr6:145611740-145640496 (+)
C3H/HeJ MGP_C3HHeJ_G0031196
 protein coding gene Chr6:150247506-150269134 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031936
 protein coding gene Chr6:155926974-155949430 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029060
 protein coding gene Chr6:144598369-144621150 (+)
CAST/EiJ MGP_CASTEiJ_G0030565
 protein coding gene Chr6:149886352-149908854 (+)
CBA/J MGP_CBAJ_G0031156
 protein coding gene Chr6:161880619-161911426 (+)
DBA/2J MGP_DBA2J_G0031312
 protein coding gene Chr6:144637917-144659483 (+)
FVB/NJ MGP_FVBNJ_G0031264
 protein coding gene Chr6:143379732-143403103 (+)
LP/J MGP_LPJ_G0031398
 protein coding gene Chr6:151961994-151987927 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031304
 protein coding gene Chr6:165603201-165629996 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031969
 protein coding gene Chr6:150019680-150042320 (+)
PWK/PhJ MGP_PWKPhJ_G0030291
 protein coding gene Chr6:143161686-143183323 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030115
 protein coding gene Chr6:148169514-148194396 (+)
WSB/EiJ MGP_WSBEiJ_G0030658
 protein coding gene Chr6:150638496-150661573 (+)



Homology
more
  • Human Ortholog
    SMCO2, single-pass membrane protein with coiled-coil domains 2
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SMCO2, single-pass membrane protein with coiled-coil domains 2
  • Synonyms
    C12orf70
  • Links
    NCBI Gene ID: 341346
    neXtProt AC: NX_A6NFE2
    UniProt: A6NFE2

  • Chr Location
    12p11.23; chr12:27423316-27502185 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    8 phenotype references
Mice homozygous for a knock-out allele are viable and display normal male fertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    1
  • GO References
    1
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 69371 NCBI Gene Model | MGI Sequence Detail 21295 C57BL/6J ±  kb
transcript NM_027059 RefSeq | MGI Sequence Detail 1268 C57BL/6  
polypeptide Q9DA21 UniProt | EBI | MGI Sequence Detail 347 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000059695 single-pass membrane and coiled-coil domain-containing protein 2
    (term hierarchy)
  • InterPro Domains
    IPR026617 Transmembrane and coiled-coil domain-containing protein 2/5
Molecular
Reagents
less
  • All nucleic 2
    cDNA 2

    Microarray probesets 3
References
more
  • Summaries
    All 27
    Gene Ontology 1
    Phenotypes 8
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory