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Pir Gene Detail
Summary
  • Symbol
    Pir
  • Name
    pirin
  • Synonyms
    2310042L19Rik, iron-binding nuclear protein, pirin, Pirnl
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916906
    NCBI Gene: 69656
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:163052427-163156009 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 76.12 cM, cytoband F5
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2074 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916906
 protein coding gene ChrX:163052367-163156009 (+)
129S1/SvImJ MGP_129S1SvImJ_G0036254
 protein coding gene ChrX:162355450-162458995 (+)
A/J MGP_AJ_G0036224
 protein coding gene ChrX:161531630-161634523 (+)
AKR/J MGP_AKRJ_G0036152
 protein coding gene ChrX:166718962-166823066 (+)
BALB/cJ MGP_BALBcJ_G0036217
 protein coding gene ChrX:159527206-159630333 (+)
C3H/HeJ MGP_C3HHeJ_G0035924
 protein coding gene ChrX:162697586-162802354 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036740
 protein coding gene ChrX:167109082-167210924 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033560
 protein coding gene ChrX:152570138-152668471 (+)
CAST/EiJ MGP_CASTEiJ_G0035212
 protein coding gene ChrX:141690024-141784750 (+)
CBA/J MGP_CBAJ_G0035898
 protein coding gene ChrX:171947416-172079088 (+)
DBA/2J MGP_DBA2J_G0036064
 protein coding gene ChrX:160408978-160504022 (+)
FVB/NJ MGP_FVBNJ_G0035996
 protein coding gene ChrX:159546162-159644376 (+)
LP/J MGP_LPJ_G0036149
 protein coding gene ChrX:163490186-163591638 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0036028
 protein coding gene ChrX:180641336-180742326 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036779
 protein coding gene ChrX:161841376-161944260 (+)
PWK/PhJ MGP_PWKPhJ_G0034910
 protein coding gene ChrX:138458772-138560049 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034731
 protein coding gene ChrX:142188616-142287443 (+)
WSB/EiJ MGP_WSBEiJ_G0035347
 protein coding gene ChrX:159809044-159909011 (+)



Homology
more
  • Human Ortholog
    PIR, pirin
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PIR, pirin
  • Links
    NCBI Gene ID: 8544
    neXtProt AC: NX_O00625
    UniProt: O00625

  • Chr Location
    Xp22.2; chrX:15384799-15493564 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    5 images
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
About one fifth of male chimeras hemizygous for a gene trapped allele exhibit a developmental delay.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    709
  • Tissues
    3
  • cDNA Data
    23
  • Literature Summary
    1
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 69656 NCBI Gene Model | MGI Sequence Detail 103583 C57BL/6J ±  kb
transcript NM_027153 RefSeq | MGI Sequence Detail 1601 C57BL/6  
polypeptide Q9D711 UniProt | EBI | MGI Sequence Detail 290 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 26
    cDNA 26

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-39585, MGI:109586
References
more
  • Summaries
    All 41
    Developmental Gene Expression 1
    Gene Ontology 7
    Phenotypes 10
  • Earliest
    J:39297 Wendler WMF, et al., Identification of pirin, a novel highly conserved nuclear protein. J Biol Chem. 1997 Mar 28;272(13):8482-9
  • Latest
    J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory