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Nkiras1 Gene Detail
Summary
  • Symbol
    Nkiras1
  • Name
    NFKB inhibitor interacting Ras-like protein 1
  • Synonyms
    2400004O09Rik, KBRAS1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916971
    NCBI Gene: 69721
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:4185693-4198560 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 7.08 cM, cytoband A3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    322 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916971
 protein coding gene Chr14:4185693-4198560 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021020
 protein coding gene Chr14:10881412-10895322 (+)
A/J MGP_AJ_G0020969
 protein coding gene Chr14:10566671-10579617 (+)
AKR/J MGP_AKRJ_G0020946
 protein coding gene Chr14:10882794-10896820 (+)
BALB/cJ MGP_BALBcJ_G0020972
 protein coding gene Chr14:10629537-10641457 (+)
C3H/HeJ MGP_C3HHeJ_G0020756
 protein coding gene Chr14:10964324-10976423 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021405
 protein coding gene Chr14:11274269-11290687 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018974
 protein coding gene Chr14:11071308-11088216 (+)
CAST/EiJ MGP_CASTEiJ_G0020279
 protein coding gene Chr14:10828444-10840864 (+)
CBA/J MGP_CBAJ_G0020722
 protein coding gene Chr14:11749833-11766221 (+)
DBA/2J MGP_DBA2J_G0020845
 protein coding gene Chr14:10466874-10479570 (+)
FVB/NJ MGP_FVBNJ_G0020828
 protein coding gene Chr14:10337103-10349991 (+)
LP/J MGP_LPJ_G0020921
 protein coding gene Chr14:10948842-10959427 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020854
 protein coding gene Chr14:11630440-11649757 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021437
 protein coding gene Chr14:10765575-10780121 (+)
PWK/PhJ MGP_PWKPhJ_G0020030
 protein coding gene Chr14:10527304-10539699 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019850
 protein coding gene Chr14:10897236-10909297 (+)
WSB/EiJ MGP_WSBEiJ_G0020335
 protein coding gene Chr14:10813389-10831668 (+)



Homology
more
  • Human Ortholog
    NKIRAS1, NFKB inhibitor interacting Ras like 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NKIRAS1, NFKB inhibitor interacting Ras like 1
  • Synonyms
    kappaB-Ras1, KBRAS1
  • Links
    NCBI Gene ID: 28512
    neXtProt AC: NX_Q9NYS0
    UniProt: Q9NYS0

  • Chr Location
    3p24.2; chr3:23889951-23946591 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    724
  • Tissues
    9
  • cDNA Data
    41
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 69721 NCBI Gene Model | MGI Sequence Detail 12868 C57BL/6J ±  kb
    transcript NM_001316711 RefSeq | MGI Sequence Detail 4868 Not Specified  
    polypeptide Q8CEC5 UniProt | EBI | MGI Sequence Detail 192 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000011235 NF-kappa-B inhibitor-interacting Ras-like protein 1
      (term hierarchy)
    • InterPro Domains
      IPR042227 NF-kappa-B inhibitor-interacting Ras-like protein
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
      IPR001806 Small GTPase
      IPR005225 Small GTP-binding protein domain
    Molecular
    Reagents
    less
    • All nucleic 41
      cDNA 41

      Microarray probesets 3
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 1
      Gene Ontology 6
      Phenotypes 9
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:347981 Postler TS, et al., A pan-cancer analysis implicates human NKIRAS1 as a tumor-suppressor gene. Proc Natl Acad Sci U S A. 2023 Nov 14;120(46):e2312595120
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory