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Smap2 Gene Detail
Summary
  • Symbol
    Smap2
  • Name
    small ArfGAP 2
  • Synonyms
    1810031K02Rik, Smap1l, Smap2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917030
    NCBI Gene: 69780
  • Alliance
    gene page
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:120825514-120874444 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 56.70 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1188 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917030
 protein coding gene Chr4:120825514-120874497 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028718
 protein coding gene Chr4:122268088-122316910 (-)
A/J MGP_AJ_G0028678
 protein coding gene Chr4:117438737-117487364 (-)
AKR/J MGP_AKRJ_G0028631
 protein coding gene Chr4:120028721-120081774 (-)
BALB/cJ MGP_BALBcJ_G0028701
 protein coding gene Chr4:118053220-118102172 (-)
C3H/HeJ MGP_C3HHeJ_G0028416
 protein coding gene Chr4:121556827-121606584 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029142
 protein coding gene Chr4:126874248-126923703 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026419
 protein coding gene Chr4:111484079-111532247 (-)
CAST/EiJ MGP_CASTEiJ_G0027847
 protein coding gene Chr4:118929094-118979627 (-)
CBA/J MGP_CBAJ_G0028383
 protein coding gene Chr4:130314526-130363349 (-)
DBA/2J MGP_DBA2J_G0028530
 protein coding gene Chr4:118014964-118063851 (-)
FVB/NJ MGP_FVBNJ_G0028496
 protein coding gene Chr4:116539530-116588302 (-)
LP/J MGP_LPJ_G0028630
 protein coding gene Chr4:122390434-122439255 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028524
 protein coding gene Chr4:135120730-135170407 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029179
 protein coding gene Chr4:121105460-121154517 (-)
PWK/PhJ MGP_PWKPhJ_G0027570
 protein coding gene Chr4:114964967-115015392 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027396
 protein coding gene Chr4:117522400-117573897 (-)
WSB/EiJ MGP_WSBEiJ_G0027927
 protein coding gene Chr4:121119819-121168654 (-)



Homology
more
  • Human Ortholog
    SMAP2, small ArfGAP2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SMAP2, small ArfGAP2
  • Synonyms
    SMAP1L
  • Links
    NCBI Gene ID: 64744
    neXtProt AC: NX_Q8WU79
    UniProt: Q8WU79

  • Chr Location
    1p34.2; chr1:40344834-40423326 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 1 allele in 1 genetic background
    4 phenotypes from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit male infertility associated with globozoospermia, asthenozoospermia and abnormal acrosome formation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    772
  • Tissues
    25
  • cDNA Data
    76
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032870 Ensembl Gene Model | MGI Sequence Detail 48931 C57BL/6J ±  kb
    transcript ENSMUST00000043200 Ensembl | MGI Sequence Detail 2905 Not Applicable  
    polypeptide ENSMUSP00000035800 Ensembl | MGI Sequence Detail 428 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 77
      cDNA 76
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2140133
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 3
      Gene Ontology 5
      Phenotypes 15
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:226700 Sumiyoshi M, et al., Mice doubly-deficient in the Arf GAPs SMAP1 and SMAP2 exhibit embryonic lethality. FEBS Lett. 2015 Sep 14;589(19 Pt B):2754-62
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory