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Trim32 Gene Detail
Summary
  • Symbol
    Trim32
  • Name
    tripartite motif-containing 32
  • Synonyms
    1810045E12Rik, 3f3, BBS11, Zfp117
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917057
    NCBI Gene: 69807
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:65523223-65534475 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 34.43 cM, cytoband C1
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    316 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917057
 protein coding gene Chr4:65523223-65534477 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028378
 protein coding gene Chr4:64686726-64697974 (+)
A/J MGP_AJ_G0028339
 protein coding gene Chr4:62378167-62389428 (+)
AKR/J MGP_AKRJ_G0028288
 protein coding gene Chr4:64048892-64061570 (+)
BALB/cJ MGP_BALBcJ_G0028359
 protein coding gene Chr4:62595916-62607199 (+)
C3H/HeJ MGP_C3HHeJ_G0028074
 protein coding gene Chr4:64612871-64624736 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028799
 protein coding gene Chr4:66914373-66925906 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026102
 protein coding gene Chr4:59591738-59602790 (+)
CAST/EiJ MGP_CASTEiJ_G0027515
 protein coding gene Chr4:62586300-62600991 (+)
CBA/J MGP_CBAJ_G0028043
 protein coding gene Chr4:69242906-69259286 (+)
DBA/2J MGP_DBA2J_G0028192
 protein coding gene Chr4:62198773-62213655 (+)
FVB/NJ MGP_FVBNJ_G0028158
 protein coding gene Chr4:61448214-61459496 (+)
LP/J MGP_LPJ_G0028291
 protein coding gene Chr4:64962743-64973990 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028187
 protein coding gene Chr4:72406568-72417855 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028835
 protein coding gene Chr4:64188127-64200841 (+)
PWK/PhJ MGP_PWKPhJ_G0027242
 protein coding gene Chr4:60763418-60774838 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027068
 protein coding gene Chr4:61696504-61707411 (+)
WSB/EiJ MGP_WSBEiJ_G0027592
 protein coding gene Chr4:64248336-64262914 (+)



Homology
more
  • Human Ortholog
    TRIM32, tripartite motif containing 32
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRIM32, tripartite motif containing 32
  • Synonyms
    BBS11, HT2A, LGMD2H, LGMDR8, TATIP
  • Links
    NCBI Gene ID: 22954
    neXtProt AC: NX_Q13049
    UniProt: Q13049

  • Chr Location
    9q33.1; chr9:116687305-116701300 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Trim32 mouse models; 4 with human TRIM32 associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 3 alleles in 3 genetic backgrounds
    1 images
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele exhibit mild myopathy with sarcotubular myopathy, decreased fertility, and decreased axon diameter. Mice homozygous for a knock-out allele exhibit impaired adult muscle regeneration and myopathy.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    99
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    727
  • Tissues
    16
  • cDNA Data
    53
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000051675 Ensembl Gene Model | MGI Sequence Detail 11253 C57BL/6J ±  kb
    transcript ENSMUST00000050850 Ensembl | MGI Sequence Detail 3194 Not Applicable  
    polypeptide ENSMUSP00000062277 Ensembl | MGI Sequence Detail 655 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 62
      Genomic 6
      cDNA 53
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1341837, MGI:1341880
    References
    more
    • Summaries
      All 71
      Developmental Gene Expression 9
      Diseases 2
      Gene Ontology 16
      Phenotypes 21
    • Earliest
      J:53343 Qureshi ST, et al., Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4) [see comments]. J Exp Med. 1999 Feb 15;189(4):615-25
    • Latest
      J:320749 Sun YY, et al., TRIM32 Deficiency Impairs the Generation of Pyramidal Neurons in Developing Cerebral Cortex. Cells. 2022 Jan 28;11(3)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory