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Rcbtb2 Gene Detail
Summary
  • Symbol
    Rcbtb2
  • Name
    regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
  • Synonyms
    2610028E02Rik, 2810420M18Rik, Chc1l, Rc/btb2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917200
    NCBI Gene: 105670
  • Alliance
    gene page
  • Transcription Start Sites
    22 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:73376185-73421495 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 38.66 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1609 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917200
 protein coding gene Chr14:73360477-73445283 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021554
 protein coding gene Chr14:67881757-67944712 (+)
A/J MGP_AJ_G0021513
 protein coding gene Chr14:66393327-66456096 (+)
AKR/J MGP_AKRJ_G0021489
 protein coding gene Chr14:68348335-68411779 (+)
BALB/cJ MGP_BALBcJ_G0021519
 protein coding gene Chr14:66156504-66223174 (+)
C3H/HeJ MGP_C3HHeJ_G0021296
 protein coding gene Chr14:68069149-68131484 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021960
 protein coding gene Chr14:70866442-70935656 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019498
 protein coding gene Chr14:64083978-64180149 (+)
CAST/EiJ MGP_CASTEiJ_G0020814
 protein coding gene Chr14:64732095-64796644 (+)
CBA/J MGP_CBAJ_G0021264
 protein coding gene Chr14:73096655-73162243 (+)
DBA/2J MGP_DBA2J_G0021387
 protein coding gene Chr14:65776681-65838679 (+)
FVB/NJ MGP_FVBNJ_G0021365
 protein coding gene Chr14:65159634-65223033 (+)
LP/J MGP_LPJ_G0021457
 protein coding gene Chr14:69052971-69114577 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021394
 protein coding gene Chr14:71933061-71994769 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021982
 protein coding gene Chr14:67615511-67680698 (+)
PWK/PhJ MGP_PWKPhJ_G0020557
 protein coding gene Chr14:62548723-62612168 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020392
 protein coding gene Chr14:63573819-63650505 (+)
WSB/EiJ MGP_WSBEiJ_G0020867
 protein coding gene Chr14:67971945-68034334 (+)



Homology
more
  • Human Ortholog
    RCBTB2, RCC1 and BTB domain containing protein 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RCBTB2, RCC1 and BTB domain containing protein 2
  • Synonyms
    CHC1L, RLG
  • Links
    NCBI Gene ID: 1102
    neXtProt AC: NX_O95199
    UniProt: O95199

  • Chr Location
    13q14.2; chr13:48488963-48535895 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Rcbtb2 mouse models

Human Disease Mouse Models
      
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous or heterozygous for a null allele display increased incidence of histiocytic sarcomas.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    3
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 105670 NCBI Gene Model | MGI Sequence Detail 45311 C57BL/6J ±  kb
    transcript NR_033185 RefSeq | MGI Sequence Detail 3773 C57BL/6  
    polypeptide Q99LJ7 UniProt | EBI | MGI Sequence Detail 551 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      14 Sequences
    • Protein Ontology
      PR:000030818 RCC1 and BTB domain-containing protein 2
      (term hierarchy)
    • InterPro Domains
      IPR000210 BTB/POZ domain
      IPR051481 BTB/POZ domain-containing protein and Galectin-3-binding
      IPR051625 Diverse Signaling and Regulatory Domain-Containing Protein
      IPR009091 Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II
      IPR000408 Regulator of chromosome condensation, RCC1
      IPR011333 SKP1/BTB/POZ domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 15

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1919062, MGI:2145647, MGI:2145809
    References
    more
    • Summaries
      All 29
      Diseases 1
      Gene Ontology 3
      Phenotypes 7
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:282928 Spillane DR, et al., Chromosome Condensation 1-Like (Chc1L) Is a Novel Tumor Suppressor Involved in Development of Histiocyte-Rich Neoplasms. PLoS One. 2015;10(8):e0135755
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory