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Gpr15lg Gene Detail
Summary
  • Symbol
    Gpr15lg
  • Name
    G protein coupled receptor 15 ligand
  • Synonyms
    2610528A11Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917295
    NCBI Gene: 70045
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:36824097-36832058 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 21.29 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    362 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917295
 protein coding gene Chr14:36824097-36835979 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021188
 protein coding gene Chr14:30603026-30616151 (-)
A/J MGP_AJ_G0021136
 protein coding gene Chr14:29338253-29350036 (-)
AKR/J MGP_AKRJ_G0021113
 protein coding gene Chr14:30675975-30687770 (-)
BALB/cJ MGP_BALBcJ_G0021140
 protein coding gene Chr14:29570328-29582388 (-)
C3H/HeJ MGP_C3HHeJ_G0020923
 protein coding gene Chr14:30557892-30570342 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021572
 protein coding gene Chr14:31699594-31711385 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019134
 protein coding gene Chr14:29322211-29333813 (-)
CAST/EiJ MGP_CASTEiJ_G0020448
 protein coding gene Chr14:30445336-30457459 (-)
CBA/J MGP_CBAJ_G0020889
 protein coding gene Chr14:32881868-32896647 (-)
DBA/2J MGP_DBA2J_G0021012
 protein coding gene Chr14:29378817-29390415 (-)
FVB/NJ MGP_FVBNJ_G0020996
 protein coding gene Chr14:29355911-29367544 (-)
LP/J MGP_LPJ_G0021081
 protein coding gene Chr14:30898346-30910375 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021022
 protein coding gene Chr14:32084309-32097177 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021605
 protein coding gene Chr14:30537661-30550695 (-)
PWK/PhJ MGP_PWKPhJ_G0020196
 protein coding gene Chr14:28923003-28934795 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020020
 protein coding gene Chr14:30087745-30106697 (-)
WSB/EiJ MGP_WSBEiJ_G0020503
 protein coding gene Chr14:30564059-30575894 (-)



Homology
more
  • Human Ortholog
    GPR15LG, G protein-coupled receptor 15 ligand
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GPR15LG, G protein-coupled receptor 15 ligand
  • Synonyms
    AP-57, AP57, C10orf99, CSBF, GPR15L, UNQ1833
  • Links
    NCBI Gene ID: 387695
    neXtProt AC: NX_Q6UWK7
    UniProt: Q6UWK7

  • Chr Location
    10q23.1; chr10:84173801-84185294 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice exhibit an increased mean serum IgG2a response to ovalbumin challenge.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    707
  • Tissues
    1
  • cDNA Data
    48
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 70045 NCBI Gene Model | MGI Sequence Detail 7962 C57BL/6J ±  kb
transcript NM_001206684 RefSeq | MGI Sequence Detail 756 C57BL/6  
polypeptide A0A0B4J1N3 UniProt | EBI | MGI Sequence Detail 78 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 48
    cDNA 48

    Microarray probesets 3
Other
Accession IDs
less
MGI:2145819, MGI:7384681
References
more
  • Summaries
    All 29
    Developmental Gene Expression 1
    Gene Ontology 7
    Phenotypes 6
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:326779 Tseng PY, et al., GPR15L is an epithelial inflammation-derived pruritogen. Sci Adv. 2022 Jun 17;8(24):eabm7342
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory