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Poc1a Gene Detail
Summary
  • Symbol
    Poc1a
  • Name
    POC1 centriolar protein A
  • Synonyms
    2510040D07Rik, cha, Wdr51a
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917485
    NCBI Gene: 70235
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:106158260-106227720 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 57.46 cM, cytoband F1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1836 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917485
 protein coding gene Chr9:106156177-106227721 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035226
 protein coding gene Chr9:108079892-108149408 (+)
A/J MGP_AJ_G0035206
 protein coding gene Chr9:104177246-104246393 (+)
AKR/J MGP_AKRJ_G0035138
 protein coding gene Chr9:106773003-106842146 (+)
BALB/cJ MGP_BALBcJ_G0035199
 protein coding gene Chr9:103860611-103930502 (+)
C3H/HeJ MGP_C3HHeJ_G0034909
 protein coding gene Chr9:107181706-107251794 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035719
 protein coding gene Chr9:111050909-111123826 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032617
 protein coding gene Chr9:101668426-101737480 (+)
CAST/EiJ MGP_CASTEiJ_G0034221
 protein coding gene Chr9:107077482-107150650 (+)
CBA/J MGP_CBAJ_G0034878
 protein coding gene Chr9:114947992-115040585 (+)
DBA/2J MGP_DBA2J_G0035039
 protein coding gene Chr9:103636694-103706003 (+)
FVB/NJ MGP_FVBNJ_G0034987
 protein coding gene Chr9:102413483-102484527 (+)
LP/J MGP_LPJ_G0035115
 protein coding gene Chr9:108298846-108370219 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035026
 protein coding gene Chr9:116593521-116663060 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035741
 protein coding gene Chr9:107014620-107086222 (+)
PWK/PhJ MGP_PWKPhJ_G0033928
 protein coding gene Chr9:103930169-104001275 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033763
 protein coding gene Chr9:107076278-107149055 (+)
WSB/EiJ MGP_WSBEiJ_G0034341
 protein coding gene Chr9:106914461-106985581 (+)



Homology
more
  • Human Ortholog
    POC1A, POC1 centriolar protein A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    POC1A, POC1 centriolar protein A
  • Synonyms
    PIX2, SOFT, WDR51A
  • Links
    NCBI Gene ID: 25886
    neXtProt AC: NX_Q8NBT0
    UniProt: Q8NBT0

  • Chr Location
    3p21.2; chr3:52075226-52154690 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 2 alleles in 4 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for this mutation exhibit disproportionate dwarfism and male infertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    4
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    711
  • Tissues
    5
  • cDNA Data
    35
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000023345 Ensembl Gene Model | MGI Sequence Detail 69461 C57BL/6J ±  kb
    transcript ENSMUST00000216306 Ensembl | MGI Sequence Detail 1308 Not Applicable  
    polypeptide ENSMUSP00000149444 Ensembl | MGI Sequence Detail 428 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 36
      cDNA 36

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2135613
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 1
      Gene Ontology 4
      Phenotypes 10
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory