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Rnf126 Gene Detail
Summary
  • Symbol
    Rnf126
  • Name
    ring finger protein 126
  • Synonyms
    2610010O19Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917544
    NCBI Gene: 70294
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:79594349-79602786 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 39.72 cM, cytoband C1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    182 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917544
 protein coding gene Chr10:79594349-79607282 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017458
 protein coding gene Chr10:80300590-80309954 (-)
A/J MGP_AJ_G0017436
 protein coding gene Chr10:77512171-77520600 (-)
AKR/J MGP_AKRJ_G0017397
 protein coding gene Chr10:79619570-79628005 (-)
BALB/cJ MGP_BALBcJ_G0017398
 protein coding gene Chr10:77737869-77746292 (-)
C3H/HeJ MGP_C3HHeJ_G0017221
 protein coding gene Chr10:79727332-79735787 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017852
 protein coding gene Chr10:83075661-83084099 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015540
 protein coding gene Chr10:73736854-73745343 (-)
CAST/EiJ MGP_CASTEiJ_G0016788
 protein coding gene Chr10:79899612-79908017 (-)
CBA/J MGP_CBAJ_G0017193
 protein coding gene Chr10:86299616-86308030 (-)
DBA/2J MGP_DBA2J_G0017299
 protein coding gene Chr10:76726908-76735327 (-)
FVB/NJ MGP_FVBNJ_G0017293
 protein coding gene Chr10:75893487-75902008 (-)
LP/J MGP_LPJ_G0017370
 protein coding gene Chr10:80783128-80791566 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017319
 protein coding gene Chr10:88279535-88288000 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017893
 protein coding gene Chr10:79595073-79604720 (-)
PWK/PhJ MGP_PWKPhJ_G0016569
 protein coding gene Chr10:76585654-76594043 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016358
 protein coding gene Chr10:78571547-78580101 (-)
WSB/EiJ MGP_WSBEiJ_G0016848
 protein coding gene Chr10:79626812-79635239 (-)



Homology
more
  • Human Ortholog
    RNF126, ring finger protein 126
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RNF126, ring finger protein 126
  • Links
    NCBI Gene ID: 55658
    neXtProt AC: NX_Q9BV68
    UniProt: Q9BV68

  • Chr Location
    19p13.3; chr19:647526-663233 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 3 alleles in 3 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice show partial prenatal lethality and shorter survival time and increased cellular apoptosis following irradiation exposure.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    42
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    81
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000035890 Ensembl Gene Model | MGI Sequence Detail 8438 C57BL/6J ±  kb
    transcript ENSMUST00000047203 Ensembl | MGI Sequence Detail 1639 Not Applicable  
    polypeptide ENSMUSP00000039486 Ensembl | MGI Sequence Detail 313 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 81
      cDNA 81

      Microarray probesets 4
    References
    more
    • Summaries
      All 45
      Gene Ontology 6
      Phenotypes 19
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory