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Stk26 Gene Detail
Summary
  • Symbol
    Stk26
  • Name
    serine/threonine kinase 26
  • Synonyms
    2610018G03Rik, Mst4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917665
    NCBI Gene: 70415
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:49930052-49981980 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 27.50 cM, cytoband A3.3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    867 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917665
 protein coding gene ChrX:49929924-49981980 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035708
 protein coding gene ChrX:45985933-46038484 (+)
A/J MGP_AJ_G0035691
 protein coding gene ChrX:45857754-45917975 (+)
AKR/J MGP_AKRJ_G0035611
 protein coding gene ChrX:47122914-47175326 (+)
BALB/cJ MGP_BALBcJ_G0035677
 protein coding gene ChrX:45456957-45509066 (+)
C3H/HeJ MGP_C3HHeJ_G0035381
 protein coding gene ChrX:46253780-46312287 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036206
 protein coding gene ChrX:47098736-47151484 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033058
 protein coding gene ChrX:43431689-43483561 (+)
CAST/EiJ MGP_CASTEiJ_G0034672
 protein coding gene ChrX:33710178-33764919 (+)
CBA/J MGP_CBAJ_G0035355
 protein coding gene ChrX:48385347-48437918 (+)
DBA/2J MGP_DBA2J_G0035510
 protein coding gene ChrX:45695235-45746961 (+)
FVB/NJ MGP_FVBNJ_G0035458
 protein coding gene ChrX:45399425-45451591 (+)
LP/J MGP_LPJ_G0035597
 protein coding gene ChrX:46325869-46383612 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035497
 protein coding gene ChrX:49926850-49980765 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036224
 protein coding gene ChrX:45888515-45941398 (+)
PWK/PhJ MGP_PWKPhJ_G0034371
 protein coding gene ChrX:33232920-33285403 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034216
 protein coding gene ChrX:34494221-34548494 (+)
WSB/EiJ MGP_WSBEiJ_G0034816
 protein coding gene ChrX:45438286-45492484 (+)



Homology
more
  • Human Ortholog
    STK26, serine/threonine kinase 26
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    STK26, serine/threonine kinase 26
  • Synonyms
    MASK, MST4
  • Links
    NCBI Gene ID: 51765
    neXtProt AC: NX_Q9P289
    UniProt: Q9P289

  • Chr Location
    Xq26.2; chrX:132023302-132075943 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 3 alleles in 4 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous intestinal epithelial cell-specific knockout leads to reduced enterocyte proliferation and shorter small intestine.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    71
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    909
  • Tissues
    155
  • cDNA Data
    34
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 70415 NCBI Gene Model | MGI Sequence Detail 51929 C57BL/6J ±  kb
    transcript NM_001313744 RefSeq | MGI Sequence Detail 3263 C57BL/6  
    polypeptide Q99JT2 UniProt | EBI | MGI Sequence Detail 416 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000002351 serine/threonine-protein kinase 26
      (term hierarchy)
    • EC
      2.7.11.1
    • InterPro Domains
      IPR035056 MST4, kinase domain
      IPR048288 Programmed cell death protein 10, dimerisation domain
      IPR046409 Programmed cell death protein 10, dimerisation domain superfamily
      IPR017441 Protein kinase, ATP binding site
      IPR000719 Protein kinase domain
      IPR011009 Protein kinase-like domain superfamily
      IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
      IPR050629 STE20/SPS1-related Proline-Alanine-rich Kinase
    Molecular
    Reagents
    less
    • All nucleic 37
      cDNA 36
      Primer pair 1

      Microarray probesets 5
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 3
      Gene Ontology 9
      Phenotypes 11
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:348385 Eden M, et al., Mst4, a novel cardiac STRIPAK complex-associated kinase, regulates cardiomyocyte growth and survival and is upregulated in human cardiomyopathy. J Biol Chem. 2024 Apr 3;300(5):107255
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory