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Eef2kmt Gene Detail
Summary
  • Symbol
    Eef2kmt
  • Name
    eukaryotic elongation factor 2 lysine methyltransferase
  • Synonyms
    5730409G15Rik, Fam86
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917761
    NCBI Gene: 70511
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:5062019-5073820 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 2.51 cM, cytoband A2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    427 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917761
 protein coding gene Chr16:5062016-5073847 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022489
 protein coding gene Chr16:1773952-1785537 (-)
A/J MGP_AJ_G0022451
 protein coding gene Chr16:1584069-1595649 (-)
AKR/J MGP_AKRJ_G0022428
 protein coding gene Chr16:1773463-1785280 (-)
BALB/cJ MGP_BALBcJ_G0022456
 protein coding gene Chr16:1731385-1742900 (-)
C3H/HeJ MGP_C3HHeJ_G0022223
 protein coding gene Chr16:1803809-1815572 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022905
 protein coding gene Chr16:1861349-1873009 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020426
 protein coding gene Chr16:1522152-1533339 (-)
CAST/EiJ MGP_CASTEiJ_G0021749
 protein coding gene Chr16:1810773-1823806 (-)
CBA/J MGP_CBAJ_G0022192
 protein coding gene Chr16:1965755-1977278 (-)
DBA/2J MGP_DBA2J_G0022323
 protein coding gene Chr16:1674579-1689373 (-)
FVB/NJ MGP_FVBNJ_G0022298
 protein coding gene Chr16:1676102-1687618 (-)
LP/J MGP_LPJ_G0022391
 protein coding gene Chr16:1767259-1781227 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022320
 protein coding gene Chr16:1807557-1818924 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022917
 protein coding gene Chr16:1745787-1757815 (-)
PWK/PhJ MGP_PWKPhJ_G0021489
 protein coding gene Chr16:1766669-1778340 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021320
 protein coding gene Chr16:1841605-1853155 (-)
WSB/EiJ MGP_WSBEiJ_G0021798
 protein coding gene Chr16:1779035-1791373 (-)



Homology
more
  • Human Ortholog
    EEF2KMT, eukaryotic elongation factor 2 lysine methyltransferase
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EEF2KMT, eukaryotic elongation factor 2 lysine methyltransferase
  • Synonyms
    eEF2-KMT, EFM3, FAM86A, SB153
  • Links
    NCBI Gene ID: 196483
    neXtProt AC: NX_Q96G04
    UniProt: Q96G04

  • Chr Location
    16p13.3; chr16:5084284-5097795 (-)  GRCh38
  • Human Ortholog
    FAM86B1, family with sequence similarity 86 member B1 (gene/pseudogene)
  • Links
    NCBI Gene ID: 85002
    neXtProt AC: NX_Q8N7N1
    UniProt: Q8N7N1

  • Chr Location
    8p23.1; chr8:12182096-12194937 (-)  GRCh38
  • Human Ortholog
    FAM86B2, family with sequence similarity 86 member B2
  • Links
    NCBI Gene ID: 653333
    neXtProt AC: NX_P0C5J1
    UniProt: P0C5J1

  • Chr Location
    8p23.1; chr8:12424411-12436406 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    7
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 70511 NCBI Gene Model | MGI Sequence Detail 11802 C57BL/6J ±  kb
transcript NM_027446 RefSeq | MGI Sequence Detail 2140 ZRU/MplStud  
polypeptide Q3UZW7 UniProt | EBI | MGI Sequence Detail 335 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • EC
    2.1.1.-
  • InterPro Domains
    IPR029426 FAM86, N-terminal
    IPR019410 Lysine methyltransferase
    IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily
Molecular
Reagents
less
  • All nucleic 7
    cDNA 7

    Microarray probesets 3
References
more
  • Summaries
    All 36
    Gene Ontology 6
    Phenotypes 12
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:347097 Francis JW, et al., FAM86A methylation of eEF2 links mRNA translation elongation to tumorigenesis. Mol Cell. 2024 Mar 12;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory