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Angptl6 Gene Detail
Summary
  • Symbol
    Angptl6
  • Name
    angiopoietin-like 6
  • Synonyms
    6330404E11Rik, AGF, Angiopoietin-related growth factor, Arp5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917976
    NCBI Gene: 70726
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:20785104-20791023 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 7.66 cM, cytoband A3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    194 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917976
 protein coding gene Chr9:20785104-20791116 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034429
 protein coding gene Chr9:18042984-18048847 (-)
A/J MGP_AJ_G0034407
 protein coding gene Chr9:17747180-17753080 (-)
AKR/J MGP_AKRJ_G0034334
 protein coding gene Chr9:18063855-18072352 (-)
BALB/cJ MGP_BALBcJ_G0034398
 protein coding gene Chr9:17642774-17648666 (-)
C3H/HeJ MGP_C3HHeJ_G0034110
 protein coding gene Chr9:18379919-18385771 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034919
 protein coding gene Chr9:18759399-18765269 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031849
 protein coding gene Chr9:16876384-16882805 (-)
CAST/EiJ MGP_CASTEiJ_G0033433
 protein coding gene Chr9:18201623-18207504 (-)
CBA/J MGP_CBAJ_G0034083
 protein coding gene Chr9:19483047-19490358 (-)
DBA/2J MGP_DBA2J_G0034242
 protein coding gene Chr9:17735730-17741582 (-)
FVB/NJ MGP_FVBNJ_G0034185
 protein coding gene Chr9:17237220-17243071 (-)
LP/J MGP_LPJ_G0034327
 protein coding gene Chr9:18220575-18226487 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034228
 protein coding gene Chr9:21106016-21111866 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034939
 protein coding gene Chr9:18018241-18024084 (-)
PWK/PhJ MGP_PWKPhJ_G0033139
 protein coding gene Chr9:17701652-17707890 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032973
 protein coding gene Chr9:18069483-18075495 (-)
WSB/EiJ MGP_WSBEiJ_G0033548
 protein coding gene Chr9:17750425-17756293 (-)



Homology
more
  • Human Ortholog
    ANGPTL6, angiopoietin like 6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ANGPTL6, angiopoietin like 6
  • Synonyms
    AGF, ARP5
  • Links
    NCBI Gene ID: 83854
    neXtProt AC: NX_Q8NI99
    UniProt: Q8NI99

  • Chr Location
    19p13.2; chr19:10092338-10106190 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Angptl6 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    27 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Most mice homozygous for a knock-out allele die around E13 with cardiovascular defects; survivors develop obesity, lipid accumulation in skeletal muscle and liver, hyperglycemia and hyperinsulinemia, and insulin resistance accompanied by reduced energy expenditure and whole-body oxygen consumption.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    713
  • Tissues
    5
  • cDNA Data
    13
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000038742 Ensembl Gene Model | MGI Sequence Detail 5920 C57BL/6J ±  kb
    transcript ENSMUST00000043726 Ensembl | MGI Sequence Detail 1582 Not Applicable  
    polypeptide ENSMUSP00000035784 Ensembl | MGI Sequence Detail 457 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000004031 angiopoietin-related protein 6
      (term hierarchy)
    • InterPro Domains
      IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
      IPR014716 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
      IPR020837 Fibrinogen, conserved site
      IPR050373 Fibrinogen C-terminal domain-containing protein
      IPR036056 Fibrinogen-like, C-terminal
    • GlyGen
      Q8R0Z6 1 site
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 13

      Microarray probesets 3
    References
    more
    • Summaries
      All 34
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 5
      Phenotypes 8
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:215487 Thompson CL, et al., A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory