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Kansl3 Gene Detail
Summary
  • Symbol
    Kansl3
  • Name
    KAT8 regulatory NSL complex subunit 3
  • Synonyms
    4632411B12Rik, mKIAA1310
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918055
    NCBI Gene: 226976
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:36374811-36408262 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 15.22 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    778 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918055
 protein coding gene Chr1:36374811-36408276 (-)
129S1/SvImJ MGP_129S1SvImJ_G0015921
 protein coding gene Chr1:34861094-34896916 (-)
A/J MGP_AJ_G0015905
 protein coding gene Chr1:33928563-33962849 (-)
AKR/J MGP_AKRJ_G0015860
 protein coding gene Chr1:34414217-34447521 (-)
BALB/cJ MGP_BALBcJ_G0015859
 protein coding gene Chr1:33620868-33654969 (-)
C3H/HeJ MGP_C3HHeJ_G0015692
 protein coding gene Chr1:34597499-34636112 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016312
 protein coding gene Chr1:36437476-36485182 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014034
 protein coding gene Chr1:30982558-31018480 (-)
CAST/EiJ MGP_CASTEiJ_G0015273
 protein coding gene Chr1:34485443-34521043 (-)
CBA/J MGP_CBAJ_G0015664
 protein coding gene Chr1:37402993-37436354 (-)
DBA/2J MGP_DBA2J_G0015765
 protein coding gene Chr1:33266859-33299963 (-)
FVB/NJ MGP_FVBNJ_G0015767
 protein coding gene Chr1:32783684-32817609 (-)
LP/J MGP_LPJ_G0015835
 protein coding gene Chr1:35231002-35264201 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0015787
 protein coding gene Chr1:39635204-39669213 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016359
 protein coding gene Chr1:34434047-34469156 (-)
PWK/PhJ MGP_PWKPhJ_G0015056
 protein coding gene Chr1:33012124-33046132 (-)
SPRET/EiJ MGP_SPRETEiJ_G0014838
 protein coding gene Chr1:34390944-34427105 (-)
WSB/EiJ MGP_WSBEiJ_G0015335
 protein coding gene Chr1:34391222-34425328 (-)



Homology
more
  • Human Ortholog
    KANSL3, KAT8 regulatory NSL complex subunit 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KANSL3, KAT8 regulatory NSL complex subunit 3
  • Synonyms
    KIAA1310, NSL3, Rcd1
  • Links
    NCBI Gene ID: 55683
    neXtProt AC: NX_Q9P2N6
    UniProt: Q9P2N6

  • Chr Location
    2q11.2; chr2:96580494-96642787 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 2 alleles in 2 genetic backgrounds
    1 images
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele fail to hatch out of the zona pelucida both in vivo and in vitro, and show implantation failure and lineage-specific defects at the blastocyst stage with significantly reduced inner cell mass, epiblast, and primitive endoderm cell numbers, leading to peri-implantation lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    738
  • Tissues
    6
  • cDNA Data
    9
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000010453 Ensembl Gene Model | MGI Sequence Detail 33452 C57BL/6J ±  kb
    transcript ENSMUST00000186470 Ensembl | MGI Sequence Detail 2801 Not Applicable  
    polypeptide ENSMUSP00000140597 Ensembl | MGI Sequence Detail 903 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000032097 KAT8 regulatory NSL complex subunit 3
      (term hierarchy)
    • InterPro Domains
      IPR029058 Alpha/Beta hydrolase fold
      IPR046879 KANL3/Tex30, alpha/beta hydrolase-like domain
      IPR026555 KAT8 regulatory NSL complex subunit 3/Testis-expressed sequence 30 protein
    • GlyGen
      A2RSY1 12 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (11 sites)
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 10
      Primer pair 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2138240, MGI:2138311, MGI:2138708
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 3
      Gene Ontology 7
      Phenotypes 12
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:350482 Chander A, et al., Loss of KANSL3 leads to defective inner cell mass and early embryonic lethality. Mol Reprod Dev. 2024 May;91(5):e23760
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory