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Garin2 Gene Detail
Summary
  • Symbol
    Garin2
  • Name
    golgi associated RAB2 interactor 2
  • Synonyms
    4921509E07Rik, 4930516C23Rik, Fam71d
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918147
    NCBI Gene: 70897
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:78738309-78781290 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 35.51 cM, cytoband D2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    829 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918147
 protein coding gene Chr12:78738257-78781290 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019871
 protein coding gene Chr12:78953620-78999141 (+)
A/J MGP_AJ_G0019829
 protein coding gene Chr12:76122679-76164352 (+)
AKR/J MGP_AKRJ_G0019804
 protein coding gene Chr12:78186600-78228126 (+)
BALB/cJ MGP_BALBcJ_G0019808
 protein coding gene Chr12:76370877-76414802 (+)
C3H/HeJ MGP_C3HHeJ_G0019614
 protein coding gene Chr12:78647401-78691456 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020260
 protein coding gene Chr12:81289150-81337278 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017878
 protein coding gene Chr12:73149530-73189269 (+)
CAST/EiJ MGP_CASTEiJ_G0019164
 protein coding gene Chr12:73477877-73521997 (+)
CBA/J MGP_CBAJ_G0019584
 protein coding gene Chr12:84464382-84506504 (+)
DBA/2J MGP_DBA2J_G0019700
 protein coding gene Chr12:75749309-75787275 (+)
FVB/NJ MGP_FVBNJ_G0019686
 protein coding gene Chr12:74560856-74600879 (+)
LP/J MGP_LPJ_G0019772
 protein coding gene Chr12:78885291-78928254 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019725
 protein coding gene Chr12:87503861-87550032 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020296
 protein coding gene Chr12:77694277-77739845 (+)
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0018724
 protein coding gene Chr12:72200815-72244086 (+)
WSB/EiJ MGP_WSBEiJ_G0019217
 protein coding gene Chr12:78299599-78343498 (+)



Homology
more
  • Human Ortholog
    GARIN2, golgi associated RAB2 interactor family member 2
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GARIN2, golgi associated RAB2 interactor family member 2
  • Synonyms
    C14orf54, FAM71D, GARI-L1, GARI-L2
  • Links
    NCBI Gene ID: 161142
    neXtProt AC: NX_Q8N9W8
    UniProt: Q8N9W8

  • Chr Location
    14q23.3; chr14:67189393-67228558 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 3 alleles in 3 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
While one homozygous null allele shows no gross physical abnormalities and normal male fertility, with normal testes, sperm counts, sperm motility and spermatogenesis, another knock-out allele shows small testes in males and enlarged spleen and thymus in females.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    3
  • GO References
    1
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000056987 Ensembl Gene Model | MGI Sequence Detail 42982 C57BL/6J ±  kb
    transcript ENSMUST00000077968 Ensembl | MGI Sequence Detail 1772 Not Applicable  
    polypeptide ENSMUSP00000077119 Ensembl | MGI Sequence Detail 440 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000030917 Golgi-associated RAB2 interactor protein 2
      (term hierarchy)
    • InterPro Domains
      IPR022168 Golgi associated RAB2 interactor protein-like, Rab2B-binding domain
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 10

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1921969, MGI:6885578
    References
    more
    • Summaries
      All 31
      Gene Ontology 1
      Phenotypes 11
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:350937 Wang H, et al., Golgi associated RAB2 interactor protein family contributes to murine male fertility to various extents by assuring correct morphogenesis of sperm heads. PLoS Genet. 2024 Jun;20(6):e1011337
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory