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Phyhipl Gene Detail
Summary
  • Symbol
    Phyhipl
  • Name
    phytanoyl-CoA hydroxylase interacting protein-like
  • Synonyms
    4921522K17Rik, PHY2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918161
    NCBI Gene: 70911
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:70393516-70435121 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 36.69 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1078 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918161
 protein coding gene Chr10:70393512-70491795 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017339
 protein coding gene Chr10:70503361-70603259 (-)
A/J MGP_AJ_G0017316
 protein coding gene Chr10:68105509-68202162 (-)
AKR/J MGP_AKRJ_G0017277
 protein coding gene Chr10:69960175-70058433 (-)
BALB/cJ MGP_BALBcJ_G0017276
 protein coding gene Chr10:68303529-68400664 (-)
C3H/HeJ MGP_C3HHeJ_G0017100
 protein coding gene Chr10:69987825-70086302 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017734
 protein coding gene Chr10:73045316-73148955 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015424
 protein coding gene Chr10:64711577-64813000 (-)
CAST/EiJ MGP_CASTEiJ_G0016670
 protein coding gene Chr10:70133355-70240895 (-)
CBA/J MGP_CBAJ_G0017072
 protein coding gene Chr10:75871956-75975459 (-)
DBA/2J MGP_DBA2J_G0017177
 protein coding gene Chr10:67455063-67552100 (-)
FVB/NJ MGP_FVBNJ_G0017170
 protein coding gene Chr10:66631432-66732592 (-)
LP/J MGP_LPJ_G0017250
 protein coding gene Chr10:70967170-71066401 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017198
 protein coding gene Chr10:77954749-78063668 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017773
 protein coding gene Chr10:69915341-70013917 (-)
PWK/PhJ MGP_PWKPhJ_G0016454
 protein coding gene Chr10:67318078-67418186 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016236
 protein coding gene Chr10:69301955-69402383 (-)
WSB/EiJ MGP_WSBEiJ_G0016734
 protein coding gene Chr10:69874066-69974459 (-)



Homology
more
  • Human Ortholog
    PHYHIPL, phytanoyl-CoA 2-hydroxylase interacting protein like
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PHYHIPL, phytanoyl-CoA 2-hydroxylase interacting protein like
  • Links
    NCBI Gene ID: 84457
    neXtProt AC: NX_Q96FC7
    UniProt: Q96FC7

  • Chr Location
    10q21.1; chr10:59173597-59247774 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit abnormal cerebellar Purkinje cell morphology and innervation, decreased formation of molecular layer interneuron-Purkinje cell synapses, and impaired motor coordination.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    3
  • GO References
    3
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    817
  • Tissues
    17
  • cDNA Data
    39
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 70911 NCBI Gene Model | MGI Sequence Detail 41606 C57BL/6J ±  kb
    transcript NM_178621 RefSeq | MGI Sequence Detail 2873 C57BL/6  
    polypeptide Q8BGT8 UniProt | EBI | MGI Sequence Detail 375 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000012677 phytanoyl-CoA hydroxylase-interacting protein-like
      (term hierarchy)
    • InterPro Domains
      IPR003961 Fibronectin type III
      IPR036116 Fibronectin type III superfamily
      IPR013783 Immunoglobulin-like fold
      IPR042868 Phytanoyl-CoA hydroxylase-interacting protein-like
      IPR045545 Phytanoyl-CoA hydroxylase-interacting protein-like, C-terminal
    • GlyGen
      Q8BGT8 3 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 40
      cDNA 40

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2143557
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 2
      Gene Ontology 3
      Phenotypes 12
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:307852 Sugimoto H, et al., The Ser19Stop single nucleotide polymorphism (SNP) of human PHYHIPL affects the cerebellum in mice. Mol Brain. 2021 Mar 12;14(1):52
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory