Cep170 MGI Mouse Gene Detail - MGI:1918348

Symbol

Cep170
Name

centrosomal protein 170
Synonyms

4933426L22Rik, A330004A13Rik

Feature Type

protein coding gene
IDs

MGI:1918348
NCBI Gene: 545389
Alliance

gene page
Transcription Start Sites

13 TSS

Sequence Map

Chr1:176561219-176641633 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 82.60 cM, cytoband H3
Mapping Data

3 experiments

SNPs within 2kb

1295 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1918348	protein coding gene	Chr1:176556638-176641633 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0016845	protein coding gene	Chr1:182879771-182967499 (-)
A/J	MGP_AJ_G0016824	protein coding gene	Chr1:175505772-175586679 (-)
AKR/J	MGP_AKRJ_G0016790	protein coding gene	Chr1:180756268-180839819 (-)
BALB/cJ	MGP_BALBcJ_G0016781	protein coding gene	Chr1:176033976-176114674 (-)
C3H/HeJ	MGP_C3HHeJ_G0016607	protein coding gene	Chr1:181365254-181446952 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0017246	protein coding gene	Chr1:188915489-189001169 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014952	protein coding gene	Chr1:166794692-166878880 (-)
CAST/EiJ	MGP_CASTEiJ_G0016188	protein coding gene	Chr1:180724204-180818966 (-)
CBA/J	MGP_CBAJ_G0016580	protein coding gene	Chr1:195794399-195888219 (-)
DBA/2J	MGP_DBA2J_G0016686	protein coding gene	Chr1:174367808-174448832 (-)
FVB/NJ	MGP_FVBNJ_G0016683	protein coding gene	Chr1:172456251-172539413 (-)
LP/J	MGP_LPJ_G0016761	protein coding gene	Chr1:184070888-184154359 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016714	protein coding gene	Chr1:203018845-203113964 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017282	protein coding gene	Chr1:180494881-180575092 (-)
PWK/PhJ	MGP_PWKPhJ_G0015975	protein coding gene	Chr1:173445705-173527123 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0015752	protein coding gene	Chr1:179586731-179679418 (-)
WSB/EiJ	MGP_WSBEiJ_G0016250	protein coding gene	Chr1:180717294-180806665 (-)

Human Ortholog

CEP170, centrosomal protein 170

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CEP170, centrosomal protein 170
Synonyms

FAM68A, KAB, KIAA0470
Links

HGNC:28920

NCBI Gene ID: 9859

neXtProt AC: NX_Q5SW79

UniProt: Q5SW79
Chr Location

1q43; chr1:243124428-243255793 (-) GRCh38

MGI Vertebrate Homology

Cep170 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: CEP170
Gene Tree

Cep170

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Phenotype Summary

9 phenotype references

All Mutations and Alleles

35
Chemically induced (other)

2
Endonuclease-mediated

3
Gene trapped

30
Genomic Mutations

2 involving Cep170
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

81 strains or lines available

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All GO Annotations

12
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

75

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cep170

ZFIN cep170ab

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All Sequences

108
RefSeq

40
UniProt

8
CCDS

CCDS48461.1

Ensembl

ENSMUSG00000057335 (Evidence)
NCBI Gene

545389

			Length	Strain/Species	Flank
genomic	ENSMUSG00000057335	Ensembl Gene Model \| MGI Sequence Detail	80415	C57BL/6J	± kb
transcript	ENSMUST00000194727	Ensembl \| MGI Sequence Detail	6784	Not Applicable
polypeptide	ENSMUSP00000141793	Ensembl \| MGI Sequence Detail	1588	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000005344 centrosomal protein of 170 kDa

(term hierarchy)
InterPro Domains

IPR051176 Centrosomal and Immune Signaling Modulators

IPR029300 CEP170, C-terminal

IPR000253 Forkhead-associated (FHA) domain

IPR008984 SMAD/FHA domain superfamily
GlyGen

Q6A065 6 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (5 sites)

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All nucleic 76

cDNA 76

Microarray probesets 4

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MGI:2138171, MGI:2444094

Summaries

All 44

Gene Ontology 9

Phenotypes 9
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:305154 Wilkinson B, et al., Endogenous Cell Type-Specific Disrupted in Schizophrenia 1 Interactomes Reveal Protein Networks Associated With Neurodevelopmental Disorders. Biol Psychiatry. 2019 Feb 15;85(4):305-316

TSS for Cep170:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr15427	Chr1:176641732-176641755 (-)	-111 bp
Tssr15426	Chr1:176641636-176641699 (-)	-35 bp
Tssr15425	Chr1:176641607-176641630 (-)	14 bp
Tssr15424	Chr1:176641580-176641591 (-)	47 bp
Tssr15423	Chr1:176641509-176641526 (-)	115 bp
Tssr15422	Chr1:176641486-176641497 (-)	141 bp
Tssr15421	Chr1:176636534-176636557 (-)	5,087 bp
Tssr15420	Chr1:176624881-176624886 (-)	16,749 bp
Tssr15419	Chr1:176584464-176584467 (-)	57,167 bp
Tssr15418	Chr1:176584281-176584292 (-)	57,346 bp
Tssr15417	Chr1:176583881-176583903 (-)	57,741 bp
Tssr15414	Chr1:176562578-176562595 (-)	79,046 bp
Tssr15413	Chr1:176561775-176561779 (-)	79,856 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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