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Ppm1f Gene Detail
Summary
  • Symbol
    Ppm1f
  • Name
    protein phosphatase 1F (PP2C domain containing)
  • Synonyms
    1110021B16Rik, 4933427B07Rik, MGC:25978, mKIAA0015
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918464
    NCBI Gene: 68606
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:16714333-16745228 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 10.48 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    873 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918464
 protein coding gene Chr16:16714314-16745239 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022565
 protein coding gene Chr16:13990494-14025171 (+)
A/J MGP_AJ_G0022526
 protein coding gene Chr16:13306749-13337637 (+)
AKR/J MGP_AKRJ_G0022503
 protein coding gene Chr16:13849160-13880900 (+)
BALB/cJ MGP_BALBcJ_G0022529
 protein coding gene Chr16:13458817-13489687 (+)
C3H/HeJ MGP_C3HHeJ_G0022296
 protein coding gene Chr16:13956672-13990255 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022980
 protein coding gene Chr16:14211183-14242566 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020500
 protein coding gene Chr16:13390606-13420990 (+)
CAST/EiJ MGP_CASTEiJ_G0021824
 protein coding gene Chr16:13885953-13918479 (+)
CBA/J MGP_CBAJ_G0022267
 protein coding gene Chr16:14877987-14908899 (+)
DBA/2J MGP_DBA2J_G0022397
 protein coding gene Chr16:13245279-13276217 (+)
FVB/NJ MGP_FVBNJ_G0022373
 protein coding gene Chr16:13267932-13299441 (+)
LP/J MGP_LPJ_G0022464
 protein coding gene Chr16:13779149-13810471 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022394
 protein coding gene Chr16:14582179-14614130 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022991
 protein coding gene Chr16:13759098-13790023 (+)
PWK/PhJ MGP_PWKPhJ_G0021567
 protein coding gene Chr16:13484465-13516324 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021395
 protein coding gene Chr16:13766160-13796227 (+)
WSB/EiJ MGP_WSBEiJ_G0021871
 protein coding gene Chr16:13768781-13802508 (+)



Homology
more
  • Human Ortholog
    PPM1F, protein phosphatase, Mg2+/Mn2+ dependent 1F
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PPM1F, protein phosphatase, Mg2+/Mn2+ dependent 1F
  • Synonyms
    CAMKP, CaMKPase, FEM-2, hFEM-2, POPX2
  • Links
    NCBI Gene ID: 9647
    neXtProt AC: NX_P49593
    UniProt: P49593

  • Chr Location
    22q11.22; chr22:21919425-21952848 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted mutation are not detected at weaning. Mice heterozygous for a targeted mutation display hyperactivity and an increase in pain threshold.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    65
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1160
  • Tissues
    114
  • cDNA Data
    95
  • Literature Summary
    2
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000026181 Ensembl Gene Model | MGI Sequence Detail 30896 C57BL/6J ±  kb
transcript ENSMUST00000027373 Ensembl | MGI Sequence Detail 4922 Not Applicable  
polypeptide ENSMUSP00000027373 Ensembl | MGI Sequence Detail 452 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 96
    cDNA 95
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
less
MGI:1915856
References
more
  • Summaries
    All 40
    Developmental Gene Expression 2
    Gene Ontology 8
    Phenotypes 9
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:311874 Liu J, et al., PPM1F in hippocampal dentate gyrus regulates the depression-related behaviors by modulating neuronal excitability. Exp Neurol. 2021 Jun;340:113657
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory