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Sfpq Gene Detail
Summary
  • Symbol
    Sfpq
  • Name
    splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated)
  • Synonyms
    1110004P21Rik, 2810416M14Rik, 5730453G22Rik, 9030402K04Rik, D4Ertd314e, PSF, REP1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918764
    NCBI Gene: 71514
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:126915117-126930806 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 61.20 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    223 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918764
 protein coding gene Chr4:126914504-126944894 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028790
 protein coding gene Chr4:128748542-128764227 (+)
A/J MGP_AJ_G0028749
 protein coding gene Chr4:123674366-123690261 (+)
AKR/J MGP_AKRJ_G0028702
 protein coding gene Chr4:127069763-127085449 (+)
BALB/cJ MGP_BALBcJ_G0028772
 protein coding gene Chr4:124239925-124255620 (+)
C3H/HeJ MGP_C3HHeJ_G0028486
 protein coding gene Chr4:127143690-127160501 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029214
 protein coding gene Chr4:133634595-133651766 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026487
 protein coding gene Chr4:116787758-116803722 (+)
CAST/EiJ MGP_CASTEiJ_G0027919
 protein coding gene Chr4:125255821-125273489 (+)
CBA/J MGP_CBAJ_G0028452
 protein coding gene Chr4:136878672-136897200 (+)
DBA/2J MGP_DBA2J_G0028601
 protein coding gene Chr4:124113282-124128969 (+)
FVB/NJ MGP_FVBNJ_G0028568
 protein coding gene Chr4:122776774-122792258 (+)
LP/J MGP_LPJ_G0028702
 protein coding gene Chr4:129019409-129036439 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028594
 protein coding gene Chr4:141889893-141906181 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029252
 protein coding gene Chr4:127433495-127449162 (+)
PWK/PhJ MGP_PWKPhJ_G0027640
 protein coding gene Chr4:120611346-120627411 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027466
 protein coding gene Chr4:123260413-123276109 (+)
WSB/EiJ MGP_WSBEiJ_G0027999
 protein coding gene Chr4:127549432-127565636 (+)



Homology
more
  • Human Ortholog
    SFPQ, splicing factor proline and glutamine rich
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SFPQ, splicing factor proline and glutamine rich
  • Synonyms
    POMP100, PPP1R140, PSF
  • Links
    NCBI Gene ID: 6421
    neXtProt AC: NX_P23246
    UniProt: P23246

  • Chr Location
    1p34.3; chr1:35176378-35193446 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 4 alleles in 4 genetic backgrounds
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele die embryonically. Heterozygous gene trap mice show abnormality in entrainment of circadian rhythm.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    55
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    785
  • Tissues
    47
  • cDNA Data
    27
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028820 Ensembl Gene Model | MGI Sequence Detail 15690 C57BL/6J ±  kb
    transcript ENSMUST00000247843 Ensembl | MGI Sequence Detail 3465 Not Applicable  
    polypeptide ENSMUSP00000159529 Ensembl | MGI Sequence Detail 720 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 30
      cDNA 27
      Primer pair 3

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1196226, MGI:1915728, MGI:1917845, MGI:1925565, MGI:2140463
    References
    more
    • Summaries
      All 79
      Developmental Gene Expression 13
      Gene Ontology 18
      Phenotypes 22
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory