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Isx Gene Detail
Summary
  • Symbol
    Isx
  • Name
    intestine specific homeobox
  • Synonyms
    9130012O13Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918847
    NCBI Gene: 71597
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:75599801-75620134 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 35.54 cM, cytoband C2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    587 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918847
 protein coding gene Chr8:75599326-75620134 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033792
 protein coding gene Chr8:75305944-75326314 (+)
A/J MGP_AJ_G0033774
 protein coding gene Chr8:72354253-72373968 (+)
AKR/J MGP_AKRJ_G0033701
 protein coding gene Chr8:74559747-74581333 (+)
BALB/cJ MGP_BALBcJ_G0033768
 protein coding gene Chr8:72447202-72470187 (+)
C3H/HeJ MGP_C3HHeJ_G0033477
 protein coding gene Chr8:75115646-75137072 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034288
 protein coding gene Chr8:78237964-78261732 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031229
 protein coding gene Chr8:66626829-66646377 (+)
CAST/EiJ MGP_CASTEiJ_G0032806
 protein coding gene Chr8:74399574-74421252 (+)
CBA/J MGP_CBAJ_G0033456
 protein coding gene Chr8:80982509-81005833 (+)
DBA/2J MGP_DBA2J_G0033610
 protein coding gene Chr8:72033605-72057010 (+)
FVB/NJ MGP_FVBNJ_G0033555
 protein coding gene Chr8:71122473-71142485 (+)
LP/J MGP_LPJ_G0033699
 protein coding gene Chr8:75442937-75463744 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033598
 protein coding gene Chr8:83557445-83577461 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034305
 protein coding gene Chr8:74530857-74551581 (+)
PWK/PhJ MGP_PWKPhJ_G0032512
 protein coding gene Chr8:71303976-71325323 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032350
 protein coding gene Chr8:73405003-73425095 (+)
WSB/EiJ MGP_WSBEiJ_G0032921
 protein coding gene Chr8:74829050-74850798 (+)



Homology
more
  • Human Ortholog
    ISX, intestine specific homeobox
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ISX, intestine specific homeobox
  • Synonyms
    Pix-1, RAXLX
  • Links
    NCBI Gene ID: 91464
    neXtProt AC: NX_Q2M1V0
    UniProt: Q2M1V0

  • Chr Location
    22q12.3; chr22:35066136-35087387 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice are viable and fertile up to 1 year of age and display no histological abnormalities of the gut.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    895
  • Tissues
    126
  • cDNA Data
    10
  • Literature Summary
    10
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031621 Ensembl Gene Model | MGI Sequence Detail 20334 C57BL/6J ±  kb
transcript ENSMUST00000174427 Ensembl | MGI Sequence Detail 1026 Not Applicable  
polypeptide ENSMUSP00000134368 Ensembl | MGI Sequence Detail 242 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 14
    cDNA 10
    Primer pair 2
    Other 2

    Microarray probesets 2
References
more
  • Summaries
    All 40
    Developmental Gene Expression 10
    Gene Ontology 5
    Phenotypes 11
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:353895 Thomas LD, et al., Genetic deletion of Bco2 and Isx establishes a golden mouse model for carotenoid research. Mol Metab. 2023 May 22;73:101742
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory