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Tysnd1 Gene Detail
Summary
  • Symbol
    Tysnd1
  • Name
    trypsin domain containing 1
  • Synonyms
    1300019N10Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919017
    NCBI Gene: 71767
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:61531293-61538552 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 32.26 cM, cytoband B4
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    256 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919017
 protein coding gene Chr10:61531279-61538552 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017286
 protein coding gene Chr10:61056939-61065693 (+)
A/J MGP_AJ_G0017264
 protein coding gene Chr10:59223936-59231198 (+)
AKR/J MGP_AKRJ_G0017224
 protein coding gene Chr10:60768993-60776257 (+)
BALB/cJ MGP_BALBcJ_G0017224
 protein coding gene Chr10:59299707-59306908 (+)
C3H/HeJ MGP_C3HHeJ_G0017047
 protein coding gene Chr10:60671554-60678931 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017682
 protein coding gene Chr10:63242765-63253395 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015373
 protein coding gene Chr10:56201664-56209073 (+)
CAST/EiJ MGP_CASTEiJ_G0016618
 protein coding gene Chr10:60690606-60700628 (+)
CBA/J MGP_CBAJ_G0017019
 protein coding gene Chr10:65605986-65613196 (+)
DBA/2J MGP_DBA2J_G0017124
 protein coding gene Chr10:58495184-58502355 (+)
FVB/NJ MGP_FVBNJ_G0017118
 protein coding gene Chr10:57746847-57754085 (+)
LP/J MGP_LPJ_G0017199
 protein coding gene Chr10:61455737-61464168 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017146
 protein coding gene Chr10:67902778-67911052 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017720
 protein coding gene Chr10:60594941-60603364 (+)
PWK/PhJ MGP_PWKPhJ_G0016401
 protein coding gene Chr10:58342383-58349814 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016184
 protein coding gene Chr10:59952405-59962414 (+)
WSB/EiJ MGP_WSBEiJ_G0016682
 protein coding gene Chr10:60509699-60518031 (+)



Homology
more
  • Human Ortholog
    TYSND1, trypsin like peroxisomal matrix peptidase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TYSND1, trypsin like peroxisomal matrix peptidase 1
  • Synonyms
    NET41
  • Links
    NCBI Gene ID: 219743
    neXtProt AC: NX_Q2T9J0
    UniProt: Q2T9J0

  • Chr Location
    10q22.1; chr10:70137981-70146700 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 1 allele in 1 genetic background
    2 images
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit male infertility with globozoospermia, hypoactivity, absence acrosomal cap, indicators of liver damage, abnormal hepatocyte peroxisomes and autophagosomes and enlarged, beige livers.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    58
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020087 Ensembl Gene Model | MGI Sequence Detail 7260 C57BL/6J ±  kb
    transcript ENSMUST00000020284 Ensembl | MGI Sequence Detail 2286 Not Applicable  
    polypeptide ENSMUSP00000020284 Ensembl | MGI Sequence Detail 568 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 58
      cDNA 58

      Microarray probesets 7
    References
    more
    • Summaries
      All 34
      Gene Ontology 5
      Phenotypes 8
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:223054 Mizuno Y, et al., Tysnd1 deficiency in mice interferes with the peroxisomal localization of PTS2 enzymes, causing lipid metabolic abnormalities and male infertility. PLoS Genet. 2013;9(2):e1003286
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory