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C1qtnf1 Gene Detail
Summary
  • Symbol
    C1qtnf1
  • Name
    C1q and tumor necrosis factor related protein 1
  • Synonyms
    1600017K21Rik, CTRP1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919254
    NCBI Gene: 56745
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:118319029-118340789 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 83.17 cM, cytoband E2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    727 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919254
 protein coding gene Chr11:118319029-118342608 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019468
 protein coding gene Chr11:122751881-122773380 (+)
A/J MGP_AJ_G0019436
 protein coding gene Chr11:117315098-117337043 (+)
AKR/J MGP_AKRJ_G0019406
 protein coding gene Chr11:120870044-120893416 (+)
BALB/cJ MGP_BALBcJ_G0019411
 protein coding gene Chr11:117676527-117698777 (+)
C3H/HeJ MGP_C3HHeJ_G0019217
 protein coding gene Chr11:121180224-121202836 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019860
 protein coding gene Chr11:126515067-126536883 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017485
 protein coding gene Chr11:114314495-114335692 (+)
CAST/EiJ MGP_CASTEiJ_G0018771
 protein coding gene Chr11:122605201-122626447 (+)
CBA/J MGP_CBAJ_G0019188
 protein coding gene Chr11:131428154-131449642 (+)
DBA/2J MGP_DBA2J_G0019300
 protein coding gene Chr11:116696205-116718005 (+)
FVB/NJ MGP_FVBNJ_G0019292
 protein coding gene Chr11:116342719-116364712 (+)
LP/J MGP_LPJ_G0019370
 protein coding gene Chr11:123075388-123096804 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019325
 protein coding gene Chr11:130419659-130444477 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019899
 protein coding gene Chr11:121537485-121559020 (+)
PWK/PhJ MGP_PWKPhJ_G0018537
 protein coding gene Chr11:118081742-118105287 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018329
 protein coding gene Chr11:121258296-121279475 (+)
WSB/EiJ MGP_WSBEiJ_G0018823
 protein coding gene Chr11:121488273-121514017 (+)



Homology
more
  • Human Ortholog
    C1QTNF1, C1q and TNF related 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    C1QTNF1, C1q and TNF related 1
  • Synonyms
    CTRP1, GIP, ZSIG37
  • Links
    NCBI Gene ID: 114897
    neXtProt AC: NX_Q9BXJ1
    UniProt: Q9BXJ1

  • Chr Location
    17q25.3; chr17:79022814-79049788 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    34 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit altered glucose and lipid homeostasis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    761
  • Tissues
    11
  • cDNA Data
    74
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000017446 Ensembl Gene Model | MGI Sequence Detail 21761 C57BL/6J ±  kb
    transcript ENSMUST00000017590 Ensembl | MGI Sequence Detail 2532 Not Applicable  
    polypeptide ENSMUSP00000017590 Ensembl | MGI Sequence Detail 281 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 75
      cDNA 74
      Primer pair 1

      Microarray probesets 5
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 2
      Gene Ontology 6
      Phenotypes 11
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory