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B3gat3 Gene Detail
Summary
  • Symbol
    B3gat3
  • Name
    beta-1,3-glucuronyltransferase 3
  • Synonyms
    2810405M13Rik, GlcAT-I
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919977
    NCBI Gene: 72727
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:8897740-8904600 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 6.03 cM, cytoband A
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    171 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919977
 protein coding gene Chr19:8897738-8904600 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024822
 protein coding gene Chr19:6207841-6214956 (+)
A/J MGP_AJ_G0024790
 protein coding gene Chr19:5873211-5880069 (+)
AKR/J MGP_AKRJ_G0024765
 protein coding gene Chr19:5969111-5978027 (+)
BALB/cJ MGP_BALBcJ_G0024790
 protein coding gene Chr19:5981102-5989303 (+)
C3H/HeJ MGP_C3HHeJ_G0024556
 protein coding gene Chr19:6057804-6066223 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025237
 protein coding gene Chr19:6343915-6350469 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022666
 protein coding gene Chr19:6130460-6137149 (+)
CAST/EiJ MGP_CASTEiJ_G0024029
 protein coding gene Chr19:5708483-5715908 (+)
CBA/J MGP_CBAJ_G0024530
 protein coding gene Chr19:6461494-6468301 (+)
DBA/2J MGP_DBA2J_G0024657
 protein coding gene Chr19:5707821-5714860 (+)
FVB/NJ MGP_FVBNJ_G0024624
 protein coding gene Chr19:5778292-5785108 (+)
LP/J MGP_LPJ_G0024744
 protein coding gene Chr19:6101622-6110692 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024651
 protein coding gene Chr19:6318171-6326558 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025286
 protein coding gene Chr19:6015331-6025592 (+)
PWK/PhJ MGP_PWKPhJ_G0023774
 protein coding gene Chr19:5380484-5387700 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023579
 protein coding gene Chr19:5629339-5636278 (+)
WSB/EiJ MGP_WSBEiJ_G0024091
 protein coding gene Chr19:5986386-5993194 (+)



Homology
more
  • Human Ortholog
    B3GAT3, beta-1,3-glucuronyltransferase 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    B3GAT3, beta-1,3-glucuronyltransferase 3
  • Synonyms
    GLCATI, glcUAT-I, JDSCD
  • Links
    NCBI Gene ID: 26229
    neXtProt AC: NX_O94766
    UniProt: O94766

  • Chr Location
    11q12.3; chr11:62615296-62622154 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human B3GAT3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 3 alleles in 3 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutants die prenatally before the 8-cell stage due to failed cytokinesis, and show reduction of the synthesis of chondroitin sulfate and heparan sulfate glycosaminoglycans.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    800
  • Tissues
    94
  • cDNA Data
    60
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 72727 NCBI Gene Model | MGI Sequence Detail 6861 C57BL/6J ±  kb
    transcript NM_024256 RefSeq | MGI Sequence Detail 1599 C57BL/6  
    polypeptide P58158 UniProt | EBI | MGI Sequence Detail 335 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 62
      Genomic 1
      cDNA 61

      Microarray probesets 4
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 1
      Gene Ontology 11
      Phenotypes 8
    • Earliest
      J:324228 Kitagawa H, et al., Molecular cloning and expression of glucuronyltransferase I involved in the biosynthesis of the glycosaminoglycan-protein linkage region of proteoglycans. J Biol Chem. 1998 Mar 20;273(12):6615-8
    • Latest
      J:309727 Rios JJ, et al., Germline Saturation Mutagenesis Induces Skeletal Phenotypes in Mice. J Bone Miner Res. 2021 Aug;36(8):1548-1565
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory