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Nfatc4 Gene Detail
Summary
  • Symbol
    Nfatc4
  • Name
    nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 4
  • Synonyms
    3110041H08Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920431
    NCBI Gene: 73181
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:56062252-56071400 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 28.19 cM, cytoband C1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    255 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920431
 protein coding gene Chr14:56060601-56071400 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021373
 protein coding gene Chr14:49875410-49884425 (+)
A/J MGP_AJ_G0021332
 protein coding gene Chr14:48870172-48879321 (+)
AKR/J MGP_AKRJ_G0021308
 protein coding gene Chr14:50633312-50642943 (+)
BALB/cJ MGP_BALBcJ_G0021336
 protein coding gene Chr14:48846352-48855502 (+)
C3H/HeJ MGP_C3HHeJ_G0021116
 protein coding gene Chr14:50317043-50326195 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021774
 protein coding gene Chr14:52369945-52379082 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019321
 protein coding gene Chr14:47234858-47243940 (+)
CAST/EiJ MGP_CASTEiJ_G0020635
 protein coding gene Chr14:46569922-46579029 (+)
CBA/J MGP_CBAJ_G0021083
 protein coding gene Chr14:53935912-53945046 (+)
DBA/2J MGP_DBA2J_G0021204
 protein coding gene Chr14:48588670-48597796 (+)
FVB/NJ MGP_FVBNJ_G0021186
 protein coding gene Chr14:48039369-48048488 (+)
LP/J MGP_LPJ_G0021278
 protein coding gene Chr14:50915138-50924221 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021210
 protein coding gene Chr14:53291312-53300428 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021801
 protein coding gene Chr14:49810953-49820150 (+)
PWK/PhJ MGP_PWKPhJ_G0020382
 protein coding gene Chr14:45128454-45137753 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020210
 protein coding gene Chr14:45805984-45814969 (+)
WSB/EiJ MGP_WSBEiJ_G0020688
 protein coding gene Chr14:50089777-50098864 (+)



Homology
more
  • Human Ortholog
    NFATC4, nuclear factor of activated T cells 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NFATC4, nuclear factor of activated T cells 4
  • Synonyms
    NF-AT3, NFAT3, NF-ATC4
  • Links
    NCBI Gene ID: 4776
    neXtProt AC: NX_Q14934
    UniProt: Q14934

  • Chr Location
    14q12; chr14:24365673-24379604 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human NFATC4 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    39 phenotypes from multigenic genotypes
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are viable and overtly normal and exhibit normal embryonic heart morphology as well as normal pathophysiologic cardiac hypertrophy in response to angiotensin II infusion or aortic banding.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    71
  • GO References
    22
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    870
  • Tissues
    127
  • cDNA Data
    48
  • Literature Summary
    31
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 73181 NCBI Gene Model | MGI Sequence Detail 9149 C57BL/6J ±  kb
    transcript NM_001168346 RefSeq | MGI Sequence Detail 4036 C57BL/6  
    polypeptide Q8K120 UniProt | EBI | MGI Sequence Detail 901 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000011167 nuclear factor of activated T-cells, cytoplasmic 4
      (term hierarchy)
    • InterPro Domains
      IPR014756 Immunoglobulin E-set
      IPR013783 Immunoglobulin-like fold
      IPR002909 IPT domain
      IPR008366 Nuclear factor of activated T cells (NFAT)
      IPR008967 p53-like transcription factor, DNA-binding domain superfamily
      IPR032397 Rel homology dimerisation domain
      IPR011539 Rel homology domain, DNA-binding domain
      IPR037059 Rel homology domain (RHD), DNA-binding domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 51
      cDNA 48
      Primer pair 2
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2145795, MGI:2145827
    References
    more
    • Summaries
      All 105
      Developmental Gene Expression 31
      Diseases 1
      Gene Ontology 22
      Phenotypes 25
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory