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Rec114 Gene Detail
Summary
  • Symbol
    Rec114
  • Name
    REC114 meiotic recombination protein
  • Synonyms
    2410076I21Rik, 4930527A11Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920923
    NCBI Gene: 73673
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:58560133-58651247 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 31.79 cM, cytoband C
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2633 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920923
 protein coding gene Chr9:58560133-58729684 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034894
 protein coding gene Chr9:57958646-58047407 (-)
A/J MGP_AJ_G0034875
 protein coding gene Chr9:56076772-56170763 (-)
AKR/J MGP_AKRJ_G0034804
 protein coding gene Chr9:57375585-57465464 (-)
BALB/cJ MGP_BALBcJ_G0034867
 protein coding gene Chr9:55846285-55935628 (-)
C3H/HeJ MGP_C3HHeJ_G0034577
 protein coding gene Chr9:57865877-57963817 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035386
 protein coding gene Chr9:59570497-59663641 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032297
 protein coding gene Chr9:55351059-55440533 (-)
CAST/EiJ MGP_CASTEiJ_G0033898
 protein coding gene Chr9:57957610-58046727 (-)
CBA/J MGP_CBAJ_G0034548
 protein coding gene Chr9:61664138-61760425 (-)
DBA/2J MGP_DBA2J_G0034707
 protein coding gene Chr9:55924130-56014069 (-)
FVB/NJ MGP_FVBNJ_G0034649
 protein coding gene Chr9:55168011-55256636 (-)
LP/J MGP_LPJ_G0034790
 protein coding gene Chr9:58239170-58335146 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034692
 protein coding gene Chr9:63098481-63188078 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035408
 protein coding gene Chr9:57393632-57479869 (-)
PWK/PhJ MGP_PWKPhJ_G0033602
 protein coding gene Chr9:55989922-56075826 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033437
 protein coding gene Chr9:57676640-57768368 (-)
WSB/EiJ MGP_WSBEiJ_G0034011
 protein coding gene Chr9:57344601-57431552 (-)



Homology
more
  • Human Ortholog
    REC114, REC114 meiotic recombination protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    REC114, REC114 meiotic recombination protein
  • Synonyms
    C15orf60, CT147, OOMD10, OZEMA10
  • Links
    NCBI Gene ID: 283677
    neXtProt AC: NX_Q7Z4M0
    UniProt: Q7Z4M0

  • Chr Location
    15q24.1; chr15:73443164-73560013 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 2 alleles in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene results in meiotic defects including failure of double strand break formation and homologous synapsis, severe defects in spermatogenesis and oogenesis, and both male and female sterility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    716
  • Tissues
    8
  • cDNA Data
    28
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000074269 Ensembl Gene Model | MGI Sequence Detail 91115 C57BL/6J ±  kb
    transcript ENSMUST00000098674 Ensembl | MGI Sequence Detail 883 Not Applicable  
    polypeptide ENSMUSP00000096271 Ensembl | MGI Sequence Detail 259 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 30
      cDNA 28
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1925285
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 5
      Gene Ontology 6
      Phenotypes 6
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:342971 Xu J, et al., Essential roles of the ANKRD31-REC114 interaction in meiotic recombination and mouse spermatogenesis. Proc Natl Acad Sci U S A. 2023 Nov 21;120(47):e2310951120
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory