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Megf11 Gene Detail
Summary
  • Symbol
    Megf11
  • Name
    multiple EGF-like-domains 11
  • Synonyms
    2410080H04Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920951
    NCBI Gene: 214058
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:64292908-64616487 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 34.67 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    7881 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920951
 protein coding gene Chr9:64291556-64618584 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034942
 protein coding gene Chr9:64058742-64391441 (+)
A/J MGP_AJ_G0034922
 protein coding gene Chr9:61911139-62232963 (+)
AKR/J MGP_AKRJ_G0034852
 protein coding gene Chr9:63354303-63684858 (+)
BALB/cJ MGP_BALBcJ_G0034915
 protein coding gene Chr9:61640085-61958640 (+)
C3H/HeJ MGP_C3HHeJ_G0034625
 protein coding gene Chr9:63883687-64211636 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035434
 protein coding gene Chr9:65808216-66151606 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032345
 protein coding gene Chr9:61556138-61873104 (+)
CAST/EiJ MGP_CASTEiJ_G0033946
 protein coding gene Chr9:64049486-64382947 (+)
CBA/J MGP_CBAJ_G0034596
 protein coding gene Chr9:68081038-68433409 (+)
DBA/2J MGP_DBA2J_G0034755
 protein coding gene Chr9:61695619-62015777 (+)
FVB/NJ MGP_FVBNJ_G0034697
 protein coding gene Chr9:60994132-61320413 (+)
LP/J MGP_LPJ_G0034838
 protein coding gene Chr9:64344170-64674287 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034739
 protein coding gene Chr9:69359314-69712568 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035456
 protein coding gene Chr9:63471201-63798622 (+)
PWK/PhJ MGP_PWKPhJ_G0033650
 protein coding gene Chr9:61849146-62170038 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033484
 protein coding gene Chr9:63740687-64063885 (+)
WSB/EiJ MGP_WSBEiJ_G0034059
 protein coding gene Chr9:63361681-63691908 (+)



Homology
more
  • Human Ortholog
    MEGF11, multiple EGF like domains 11
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MEGF11, multiple EGF like domains 11
  • Links
    NCBI Gene ID: 84465
    neXtProt AC: NX_A6BM72
    UniProt: A6BM72

  • Chr Location
    15q22.31; chr15:65895079-66253756 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    2 phenotypes from multigenic genotypes
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted allele exhibit abnormal spacing of horizontal cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    722
  • Tissues
    8
  • cDNA Data
    9
  • Literature Summary
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000036466 Ensembl Gene Model | MGI Sequence Detail 323580 C57BL/6J ±  kb
transcript ENSMUST00000164113 Ensembl | MGI Sequence Detail 6018 Not Applicable  
polypeptide ENSMUSP00000128672 Ensembl | MGI Sequence Detail 1095 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 12
    cDNA 10
    Primer pair 2

    Microarray probesets 3
References
more
  • Summaries
    All 32
    Developmental Gene Expression 4
    Gene Ontology 4
    Phenotypes 8
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:290493 Peng YR, et al., Binary Fate Choice between Closely Related Interneuronal Types Is Determined by a Fezf1-Dependent Postmitotic Transcriptional Switch. Neuron. 2020 Feb 5;105(3):464-474.e6
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory