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Psd Gene Detail
Summary
  • Symbol
    Psd
  • Name
    pleckstrin and Sec7 domain containing
  • Synonyms
    1110007H17Rik, Efa6, Efa6a, Psdl
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920978
    NCBI Gene: 73728
  • Alliance
    gene page
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:46300526-46315595 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 38.80 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    267 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920978
 protein coding gene Chr19:46300524-46316566 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025204
 protein coding gene Chr19:45993046-46008122 (-)
A/J MGP_AJ_G0025180
 protein coding gene Chr19:43728823-43743896 (-)
AKR/J MGP_AKRJ_G0025149
 protein coding gene Chr19:45145713-45160807 (-)
BALB/cJ MGP_BALBcJ_G0025175
 protein coding gene Chr19:43787728-43802795 (-)
C3H/HeJ MGP_C3HHeJ_G0024935
 protein coding gene Chr19:45313389-45328465 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025618
 protein coding gene Chr19:47143301-47159908 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023032
 protein coding gene Chr19:42967528-42982603 (-)
CAST/EiJ MGP_CASTEiJ_G0024400
 protein coding gene Chr19:45110713-45128575 (-)
CBA/J MGP_CBAJ_G0024915
 protein coding gene Chr19:49499733-49514830 (-)
DBA/2J MGP_DBA2J_G0025047
 protein coding gene Chr19:43552216-43567358 (-)
FVB/NJ MGP_FVBNJ_G0025008
 protein coding gene Chr19:43329233-43344314 (-)
LP/J MGP_LPJ_G0025133
 protein coding gene Chr19:45903756-45918835 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025039
 protein coding gene Chr19:48842146-48857223 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025676
 protein coding gene Chr19:45253470-45268557 (-)
PWK/PhJ MGP_PWKPhJ_G0024149
 protein coding gene Chr19:43498591-43513775 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023953
 protein coding gene Chr19:43906186-43921268 (-)
WSB/EiJ MGP_WSBEiJ_G0024470
 protein coding gene Chr19:45395091-45410160 (-)



Homology
more
  • Human Ortholog
    PSD, pleckstrin and Sec7 domain containing
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PSD, pleckstrin and Sec7 domain containing
  • Synonyms
    EFA6, EFA6A, PSD1, TYL
  • Links
    NCBI Gene ID: 5662
    neXtProt AC: NX_A5PKW4
    UniProt: A5PKW4

  • Chr Location
    10q24.32; chr10:102402617-102421539 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    933
  • Tissues
    57
  • cDNA Data
    15
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000037126 Ensembl Gene Model | MGI Sequence Detail 15070 C57BL/6J ±  kb
    transcript ENSMUST00000225323 Ensembl | MGI Sequence Detail 3398 Not Applicable  
    polypeptide ENSMUSP00000152942 Ensembl | MGI Sequence Detail 1025 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 31
      Genomic 12
      cDNA 15
      Primer pair 3
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1195274
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 8
      Gene Ontology 5
      Phenotypes 8
    • Earliest
      J:44719 Perletti L, et al., Identification of a novel gene, PSD, adjacent to NFKB2/lyt-10, which contains Sec7 and pleckstrin-homology domains. Genomics. 1997 Dec 1;46(2):251-9
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory