About   Help   FAQ
Kif2c Gene Detail
Summary
  • Symbol
    Kif2c
  • Name
    kinesin family member 2C
  • Synonyms
    4930402F02Rik, MGC:11883
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921054
    NCBI Gene: 73804
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:117016830-117039821 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 53.42 cM, cytoband D1
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    653 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921054
 protein coding gene Chr4:117016830-117039836 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028647
 protein coding gene Chr4:118122969-118147351 (-)
A/J MGP_AJ_G0028608
 protein coding gene Chr4:113569632-113594325 (-)
AKR/J MGP_AKRJ_G0028558
 protein coding gene Chr4:116050923-116073597 (-)
BALB/cJ MGP_BALBcJ_G0028629
 protein coding gene Chr4:114199750-114222708 (-)
C3H/HeJ MGP_C3HHeJ_G0028343
 protein coding gene Chr4:117616519-117640829 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029070
 protein coding gene Chr4:122684434-122712407 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026354
 protein coding gene Chr4:107611893-107634451 (-)
CAST/EiJ MGP_CASTEiJ_G0027777
 protein coding gene Chr4:114834139-114858135 (-)
CBA/J MGP_CBAJ_G0028310
 protein coding gene Chr4:126038045-126064237 (-)
DBA/2J MGP_DBA2J_G0028458
 protein coding gene Chr4:114205891-114229066 (-)
FVB/NJ MGP_FVBNJ_G0028426
 protein coding gene Chr4:112706051-112729404 (-)
LP/J MGP_LPJ_G0028560
 protein coding gene Chr4:118303526-118329227 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028453
 protein coding gene Chr4:130985291-131015869 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029107
 protein coding gene Chr4:117199166-117224848 (-)
PWK/PhJ MGP_PWKPhJ_G0027503
 protein coding gene Chr4:111004165-111029259 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027326
 protein coding gene Chr4:113497329-113519580 (-)
WSB/EiJ MGP_WSBEiJ_G0027856
 protein coding gene Chr4:117070146-117105854 (-)



Homology
more
  • Human Ortholog
    KIF2C, kinesin family member 2C
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KIF2C, kinesin family member 2C
  • Synonyms
    CT139, KNSL6, MCAK
  • Links
    NCBI Gene ID: 11004
    neXtProt AC: NX_Q99661
    UniProt: Q99661

  • Chr Location
    1p34.1; chr1:44739818-44767767 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 2 alleles in 2 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a conditional allele activated in nerve cells exhibit reduced mushroom spine density, increased AMPAR-mediated EPSCs with increased surface AMPAR receptors, reduced freezing in response to context or tone conditioned stimulus, reduced investigation of a novel stranger, and impaired spartial working memory.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    48
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1279
  • Tissues
    91
  • cDNA Data
    12
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 73804 NCBI Gene Model | MGI Sequence Detail 22992 C57BL/6J ±  kb
    transcript NM_134471 RefSeq | MGI Sequence Detail 2840 ZRU/MplStud  
    polypeptide Q922S8 UniProt | EBI | MGI Sequence Detail 721 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 13
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-28119, MGI:104825
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 5
      Gene Ontology 9
      Phenotypes 17
    • Earliest
      J:28401 Bettenhausen B, et al., Efficient isolation of novel mouse genes differentially expressed in early postimplantation embryos. Genomics. 1995 Aug 10;28(3):436-41
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory