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Herc3 Gene Detail
Summary
  • Symbol
    Herc3
  • Name
    hect domain and RLD 3
  • Synonyms
    5730409F18Rik, MGC:30404
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921248
    NCBI Gene: 73998
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:58808450-58897383 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 27.82 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2111 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921248
 protein coding gene Chr6:58808440-58897383 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030818
 protein coding gene Chr6:58454218-58551976 (+)
A/J MGP_AJ_G0030785
 protein coding gene Chr6:55928509-56021210 (+)
AKR/J MGP_AKRJ_G0030713
 protein coding gene Chr6:57773988-57862349 (+)
BALB/cJ MGP_BALBcJ_G0030797
 protein coding gene Chr6:56216012-56311207 (+)
C3H/HeJ MGP_C3HHeJ_G0030511
 protein coding gene Chr6:57750778-57841298 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031255
 protein coding gene Chr6:59734575-59839889 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028447
 protein coding gene Chr6:52940396-53031443 (+)
CAST/EiJ MGP_CASTEiJ_G0029909
 protein coding gene Chr6:57403358-57498910 (+)
CBA/J MGP_CBAJ_G0030484
 protein coding gene Chr6:62246444-62340993 (+)
DBA/2J MGP_DBA2J_G0030635
 protein coding gene Chr6:55632409-55728362 (+)
FVB/NJ MGP_FVBNJ_G0030588
 protein coding gene Chr6:55183194-55271987 (+)
LP/J MGP_LPJ_G0030720
 protein coding gene Chr6:58386528-58479893 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030623
 protein coding gene Chr6:64904869-64996194 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031281
 protein coding gene Chr6:57626626-57726611 (+)
PWK/PhJ MGP_PWKPhJ_G0029624
 protein coding gene Chr6:55384658-55474686 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029451
 protein coding gene Chr6:56837842-56931338 (+)
WSB/EiJ MGP_WSBEiJ_G0029990
 protein coding gene Chr6:57824807-57918261 (+)



Homology
more
  • Human Ortholog
    HERC3, HECT and RLD domain containing E3 ubiquitin protein ligase 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HERC3, HECT and RLD domain containing E3 ubiquitin protein ligase 3
  • Links
    NCBI Gene ID: 8916
    neXtProt AC: NX_Q15034
    UniProt: Q15034

  • Chr Location
    4q22.1; chr4:88523810-88708541 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit abnormal hair follicle bulge morphology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    4
  • GO References
    1
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    836
  • Tissues
    40
  • cDNA Data
    80
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029804 Ensembl Gene Model | MGI Sequence Detail 88934 C57BL/6J ±  kb
    transcript ENSMUST00000041401 Ensembl | MGI Sequence Detail 4731 Not Applicable  
    polypeptide ENSMUSP00000040025 Ensembl | MGI Sequence Detail 1050 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      9 Sequences
    • InterPro Domains
      IPR000569 HECT domain
      IPR035983 HECT, E3 ligase catalytic domain
      IPR009091 Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II
      IPR000408 Regulator of chromosome condensation, RCC1
      IPR051210 Ubiquitin ligases and GEF domain-containing protein
      IPR051709 Ubiquitin ligases and GTPase regulators
      IPR044611 Ubiquitin-protein ligase E3A/B/C-like
    • GlyGen
      A6H6S0 1 site, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 80
      cDNA 80

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2141458
    References
    more
    • Summaries
      All 32
      Developmental Gene Expression 3
      Gene Ontology 1
      Phenotypes 10
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:353423 Zegeye Y, et al., E3 ubiquitin ligase Herc3 deficiency leads to accumulation of subretinal microglia and retinal neurodegeneration. Sci Rep. 2024 Feb 6;14(1):3010
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory