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Glyr1 Gene Detail
Summary
  • Symbol
    Glyr1
  • Name
    glyoxylate reductase 1 homolog (Arabidopsis)
  • Synonyms
    2810419J22Rik, 3930401K13Rik, NDF, Npac
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921272
    NCBI Gene: 74022
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:4831773-4867727 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 2.49 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    647 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921272
 protein coding gene Chr16:4831766-4867780 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022482
 protein coding gene Chr16:1540445-1579691 (-)
A/J MGP_AJ_G0022444
 protein coding gene Chr16:1348314-1384764 (-)
AKR/J MGP_AKRJ_G0022421
 protein coding gene Chr16:1546114-1583342 (-)
BALB/cJ MGP_BALBcJ_G0022449
 protein coding gene Chr16:1501651-1537547 (-)
C3H/HeJ MGP_C3HHeJ_G0022216
 protein coding gene Chr16:1566182-1604341 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022898
 protein coding gene Chr16:1627151-1663132 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020419
 protein coding gene Chr16:1281418-1318159 (-)
CAST/EiJ MGP_CASTEiJ_G0021742
 protein coding gene Chr16:1570180-1607382 (-)
CBA/J MGP_CBAJ_G0022185
 protein coding gene Chr16:1723111-1760323 (-)
DBA/2J MGP_DBA2J_G0022316
 protein coding gene Chr16:1449393-1485345 (-)
FVB/NJ MGP_FVBNJ_G0022291
 protein coding gene Chr16:1444289-1480740 (-)
LP/J MGP_LPJ_G0022384
 protein coding gene Chr16:1527619-1571751 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022313
 protein coding gene Chr16:1559141-1596042 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022910
 protein coding gene Chr16:1517494-1553522 (-)
PWK/PhJ MGP_PWKPhJ_G0021482
 protein coding gene Chr16:1526205-1562465 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021313
 protein coding gene Chr16:1603689-1640058 (-)
WSB/EiJ MGP_WSBEiJ_G0021791
 protein coding gene Chr16:1536486-1570779 (-)



Homology
more
  • Human Ortholog
    GLYR1, glyoxylate reductase 1 homolog
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GLYR1, glyoxylate reductase 1 homolog
  • Synonyms
    BM045, HIBDL, hNDF, NP60, N-PAC, NPAC
  • Links
    NCBI Gene ID: 84656
    neXtProt AC: NX_Q49A26
    UniProt: Q49A26

  • Chr Location
    16p13.3; chr16:4803203-4847288 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Glyr1 mouse models

Human Disease Mouse Models
      
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygosity for a mutation of highly conserved proline 495 leads to the death of half of newborns within the first day.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    730
  • Tissues
    21
  • cDNA Data
    226
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022536 Ensembl Gene Model | MGI Sequence Detail 35955 C57BL/6J ±  kb
    transcript ENSMUST00000115844 Ensembl | MGI Sequence Detail 3292 Not Applicable  
    polypeptide ENSMUSP00000111510 Ensembl | MGI Sequence Detail 552 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000011345 nuclear protein NP60
      (term hierarchy)
    • InterPro Domains
      IPR029154 3-hydroxyisobutyrate dehydrogenase-like, NAD-binding domain
      IPR013328 6-phosphogluconate dehydrogenase, domain 2
      IPR008927 6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily
      IPR006115 6-phosphogluconate dehydrogenase, NADP-binding
      IPR035501 Cytokine-like nuclear factor N-PAC, PWWP domain
      IPR051265 HIBADH-related NP60 subfamily
      IPR036291 NAD(P)-binding domain superfamily
      IPR000313 PWWP domain
    • GlyGen
      Q922P9 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 228
      cDNA 227
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1919993, MGI:2146652
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 6
      Phenotypes 11
    • Earliest
      J:65653 Wertz K, et al., Large-scale screen for genes involved in gonad development. Mech Dev. 2000 Nov;98(1-2):51-70
    • Latest
      J:345907 Cheng GP, et al., Deficiency of nucleosome-destabilizing factor GLYR1 dampens spermatogenesis in mice. Mol Cell Endocrinol. 2024 Feb 21;586:112194
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory