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Msl1 Gene Detail
Summary
  • Symbol
    Msl1
  • Name
    male specific lethal 1
  • Synonyms
    2810017F12Rik, 4121402D02Rik, 4930463F05Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921276
    NCBI Gene: 74026
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:98686342-98698685 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 62.67 cM, cytoband D
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    280 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921276
 protein coding gene Chr11:98684214-98698685 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019073
 protein coding gene Chr11:101399658-101413599 (+)
A/J MGP_AJ_G0019041
 protein coding gene Chr11:97152549-97164896 (+)
AKR/J MGP_AKRJ_G0019011
 protein coding gene Chr11:100161796-100174128 (+)
BALB/cJ MGP_BALBcJ_G0019015
 protein coding gene Chr11:97648869-97661224 (+)
C3H/HeJ MGP_C3HHeJ_G0018828
 protein coding gene Chr11:100306098-100321390 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019466
 protein coding gene Chr11:104501880-104514208 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017098
 protein coding gene Chr11:94711797-94724099 (+)
CAST/EiJ MGP_CASTEiJ_G0018382
 protein coding gene Chr11:101272057-101306368 (+)
CBA/J MGP_CBAJ_G0018799
 protein coding gene Chr11:108856299-108868652 (+)
DBA/2J MGP_DBA2J_G0018907
 protein coding gene Chr11:96710849-96723139 (+)
FVB/NJ MGP_FVBNJ_G0018896
 protein coding gene Chr11:96225932-96238303 (+)
LP/J MGP_LPJ_G0018977
 protein coding gene Chr11:101860898-101873286 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018923
 protein coding gene Chr11:108565992-108578317 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019506
 protein coding gene Chr11:100512469-100526478 (+)
PWK/PhJ MGP_PWKPhJ_G0018153
 protein coding gene Chr11:97752885-97765310 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017942
 protein coding gene Chr11:100254565-100267756 (+)
WSB/EiJ MGP_WSBEiJ_G0018431
 protein coding gene Chr11:100468027-100482435 (+)



Homology
more
  • Human Ortholog
    MSL1, MSL complex subunit 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MSL1, MSL complex subunit 1
  • Synonyms
    MSL-1
  • Links
    NCBI Gene ID: 339287
    neXtProt AC: NX_Q68DK7
    UniProt: Q68DK7

  • Chr Location
    17q21.1; chr17:40121971-40136917 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    720
  • Tissues
    5
  • cDNA Data
    155
  • Literature Summary
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000052915 Ensembl Gene Model | MGI Sequence Detail 12344 C57BL/6J ±  kb
transcript ENSMUST00000037915 Ensembl | MGI Sequence Detail 4593 Not Applicable  
polypeptide ENSMUSP00000042792 Ensembl | MGI Sequence Detail 616 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 156
    cDNA 155
    Primer pair 1

    Microarray probesets 9
Other
Accession IDs
less
MGI:1922153, MGI:1923804, MGI:2144043
References
more
  • Summaries
    All 49
    Developmental Gene Expression 4
    Gene Ontology 10
    Phenotypes 13
  • Earliest
    J:56548 Zheng B, et al., Engineering a mouse balancer chromosome. Nat Genet. 1999 Aug;22(4):375-8
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory