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Ddias Gene Detail
Summary
  • Symbol
    Ddias
  • Name
    DNA damage-induced apoptosis suppressor
  • Synonyms
    4632434I11Rik, noxin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921291
    NCBI Gene: 74041
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:92506734-92523455 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 51.64 cM, cytoband E2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    581 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921291
 protein coding gene Chr7:92506733-92523455 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032515
 protein coding gene Chr7:95419133-95437146 (-)
A/J MGP_AJ_G0032489
 protein coding gene Chr7:93036678-93053360 (-)
AKR/J MGP_AKRJ_G0032425
 protein coding gene Chr7:95255859-95272545 (-)
BALB/cJ MGP_BALBcJ_G0032500
 protein coding gene Chr7:92704582-92721262 (-)
C3H/HeJ MGP_C3HHeJ_G0032215
 protein coding gene Chr7:95627030-95644841 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032998
 protein coding gene Chr7:99099988-99116672 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029993
 protein coding gene Chr7:95817108-95834899 (-)
CAST/EiJ MGP_CASTEiJ_G0031542
 protein coding gene Chr7:87112478-87131982 (-)
CBA/J MGP_CBAJ_G0032182
 protein coding gene Chr7:102453858-102471664 (-)
DBA/2J MGP_DBA2J_G0032334
 protein coding gene Chr7:91466205-91483960 (-)
FVB/NJ MGP_FVBNJ_G0032290
 protein coding gene Chr7:91303732-91321837 (-)
LP/J MGP_LPJ_G0032423
 protein coding gene Chr7:96671439-96690335 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032324
 protein coding gene Chr7:103572776-103598181 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033020
 protein coding gene Chr7:94572316-94593300 (-)
PWK/PhJ MGP_PWKPhJ_G0031260
 protein coding gene Chr7:84535936-84553846 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031103
 protein coding gene Chr7:81878009-81896944 (-)
WSB/EiJ MGP_WSBEiJ_G0031659
 protein coding gene Chr7:95223729-95242283 (-)



Homology
more
  • Human Ortholog
    DDIAS, DNA damage induced apoptosis suppressor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DDIAS, DNA damage induced apoptosis suppressor
  • Synonyms
    C11orf82, noxin
  • Links
    NCBI Gene ID: 220042
    neXtProt AC: NX_Q8IXT1
    UniProt: Q8IXT1

  • Chr Location
    11q14.1; chr11:82899975-82958277 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele show an enlarged heart, several altered hematopoietic parameters, decreased number of spermatids, and increased cell death and increased cell sensitivity to induced-stress.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    4
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 74041 NCBI Gene Model | MGI Sequence Detail 16722 C57BL/6J ±  kb
    transcript NM_001368705 RefSeq | MGI Sequence Detail 3473 C57BL/6  
    polypeptide Q6NZG4 UniProt | EBI | MGI Sequence Detail 898 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 6
      cDNA 6

      Microarray probesets 3
    References
    more
    • Summaries
      All 53
      Gene Ontology 4
      Phenotypes 33
    • Earliest
      J:141526 Russell LB, et al., Analysis of the albino-locus region of the mouse. III. Time of death of prenatal lethals. Genetics. 1979 May;92(1):205-13
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory