Errfi1 MGI Mouse Gene Detail - MGI:1921405 - ERBB receptor feedback inhibitor 1

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Errfi1 Gene Detail

Symbol

Errfi1
Name

ERBB receptor feedback inhibitor 1
Synonyms

1300002F13Rik, Mig-6, RALT

Feature Type

protein coding gene
IDs

MGI:1921405
NCBI Gene: 74155
Alliance

gene page
Transcription Start Sites

17 TSS
Candidate for QTL

1 QTL

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Sequence Map

Chr4:150938376-150953349 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 81.50 cM, cytoband E1
Mapping Data

4 experiments

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SNPs within 2kb

97 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates	Select Strains
C57BL/6J	MGI_C57BL6J_1921405	protein coding gene	Chr4:150938253-150953349 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029156	protein coding gene	Chr4:154879012-154893766 (+)
A/J	MGP_AJ_G0029121	protein coding gene	Chr4:148358183-148373142 (+)
AKR/J	MGP_AKRJ_G0029069	protein coding gene	Chr4:152422398-152437370 (+)
BALB/cJ	MGP_BALBcJ_G0029137	protein coding gene	Chr4:148848790-148863936 (+)
C3H/HeJ	MGP_C3HHeJ_G0028858	protein coding gene	Chr4:152990363-153005340 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029586	protein coding gene	Chr4:160436249-160452933 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026832	protein coding gene	Chr4:140751980-140766907 (+)
CAST/EiJ	MGP_CASTEiJ_G0028271	protein coding gene	Chr4:150268161-150283049 (+)
CBA/J	MGP_CBAJ_G0028820	protein coding gene	Chr4:165189637-165206240 (+)
DBA/2J	MGP_DBA2J_G0028969	protein coding gene	Chr4:148435273-148450185 (+)
FVB/NJ	MGP_FVBNJ_G0028933	protein coding gene	Chr4:147587033-147602536 (+)
LP/J	MGP_LPJ_G0029059	protein coding gene	Chr4:154799429-154814351 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028960	protein coding gene	Chr4:168311277-168335896 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029618	protein coding gene	Chr4:152950006-152964950 (+)
PWK/PhJ	MGP_PWKPhJ_G0027991	protein coding gene	Chr4:144474578-144489537 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0027825	protein coding gene	Chr4:147193577-147208331 (+)
WSB/EiJ	MGP_WSBEiJ_G0028351	protein coding gene	Chr4:153087096-153103161 (+)

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Human Ortholog

ERRFI1, ERBB receptor feedback inhibitor 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ERRFI1, ERBB receptor feedback inhibitor 1
Synonyms

GENE-33, MIG-6, MIG6, RALT
Links

HGNC:18185

NCBI Gene ID: 54206

neXtProt AC: NX_Q9UJM3

UniProt: Q9UJM3
Chr Location

1p36.23; chr1:8004404-8026309 (-) GRCh38

MGI Vertebrate Homology

Errfi1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ERRFI1
Gene Tree

Errfi1

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Diseases

2 with Errfi1 mouse models

Human Disease

Mouse Models

Mouse gene associated with disease

endometrial cancer

IDs

View 2 models

IDs

View 1 model

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

2 with disease annotations

References

3 with disease annotations

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Phenotype Summary

56 phenotypes from 5 alleles in 8 genetic backgrounds
9 phenotypes from multigenic genotypes
11 images
35 phenotype references

Phenotype Overview

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

18
Endonuclease-mediated

3
Gene trapped

4
Targeted

11
Genomic Mutations

3 involving Errfi1
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

18 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous inactivation of this gene may lead to premature death, delayed eyelid opening, epidermal hyperplasia, degenerative joint disease, skin or lung cancer, gastrointestinal tract tumors, increased susceptibility to chemically-induced tumors, and impaired lung development and vascularization.

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All GO Annotations

92
GO References

26

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

733
Tissues

14
cDNA Data

218
Literature Summary

4

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase errfi1

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All Sequences

51
RefSeq

4
UniProt

3
CCDS

CCDS18974.1

Ensembl

ENSMUSG00000028967 (Evidence)
NCBI Gene

74155

Representative Sequences				Length	Strain/Species	Flank
	genomic	ENSMUSG00000028967	Ensembl Gene Model \| MGI Sequence Detail	14974	C57BL/6J	± kb
	transcript	ENSMUST00000073600	Ensembl \| MGI Sequence Detail	3036	Not Applicable
	polypeptide	ENSMUSP00000073285	Ensembl \| MGI Sequence Detail	461	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000007191 ERBB receptor feedback inhibitor 1

(term hierarchy)
InterPro Domains

IPR015116 Cdc42 binding domain-like

IPR052112 EGFR Signaling Regulator Kinase

IPR021619 Mig-6 domain

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All nucleic 219

cDNA 218

Primer pair 1

Microarray probesets 5

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MGI:2140358

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Summaries

All 76

Developmental Gene Expression 4

Diseases 3

Gene Ontology 26

Phenotypes 35
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:311128 Choung S, et al., Mig-6 is essential for glucose homeostasis and thermogenesis in brown adipose tissue. Biochem Biophys Res Commun. 2021 Oct 1;572:92-97

TSS for Errfi1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr40443	Chr4:150937179-150937187 (+)	-1,193 bp
Tssr40444	Chr4:150938226-150938245 (+)	-140 bp
Tssr40445	Chr4:150938252-150938269 (+)	-115 bp
Tssr40446	Chr4:150938473-150938507 (+)	114 bp
Tssr40447	Chr4:150938510-150938520 (+)	139 bp
Tssr40448	Chr4:150938827-150938842 (+)	459 bp
Tssr40449	Chr4:150939521-150939538 (+)	1,154 bp
Tssr40450	Chr4:150949830-150949865 (+)	11,472 bp
Tssr40451	Chr4:150950833-150950853 (+)	12,467 bp
Tssr40452	Chr4:150950929-150950946 (+)	12,562 bp
Tssr40453	Chr4:150951010-150951030 (+)	12,644 bp
Tssr40454	Chr4:150951264-150951289 (+)	12,901 bp
Tssr40455	Chr4:150951423-150951445 (+)	13,058 bp
Tssr40456	Chr4:150951504-150951529 (+)	13,141 bp
Tssr40457	Chr4:150951546-150951558 (+)	13,176 bp
Tssr40458	Chr4:150951726-150951771 (+)	13,373 bp
Tssr40459	Chr4:150952739-150952757 (+)	14,372 bp

Errfi1 is Candidate Gene for:

QTL	Genetic Location*	Genome Location (GRCm39)	Reference	QTL Note
Cdcs9	Chr4, 75.67 cM	Chr4:142230872-142230960	J:109420	Microarray analysis was used to identify candidate genes for colitis susceptibility QTLs. Messenger RNA was analyzed for expression differences between colitis susceptible inbred strain C3H/HeJBir-Il10 and colitis resistant inbred strain C57BL/6J-Il10. Capn3 (67.2 cM) on mouse Chromosome 2 is upregulated 1.5- to 2-fold in C3H/HeJBir-Il10 animals. This candidate gene maps to the Cdcs3 (cytokine deficiency colitis susceptibility 3) interval centered near 65 cM. Gbp1 (67.4 cM) on mouse Chromosome 3 is upregulated over 15-fold in C3H/HeJBir-Il10 animals. This candidate gene is known to be polymorphic between C3H/HeJBir and C57BL/6J and exhibits expression differences in these parental wild type strains. Gbp1 maps to the Cdcs1 (cytokine deficiency colitis susceptibility 1) interval centered near 62 cM. Adh1 at 71.2 cM and Bglap2 at 42.6 cM also map to the same QTL interval. Adh1 is upregulated 1.5- to 2-fold, and Blgap2 is upregulated 2- to 5-fold, in C3H/HeJBir-Il10animals. Pla2g2a (68 cM) on mouse Chromosome 4 is upregulated over 15-fold in C3H/HeJBir-Il10 animals. This candidate gene is known to be polymorphic between C3H/HeJBir and C57BL/6J and exhibits expression differences in these parental wild typestrains. Pla2g2a maps to the Cdcs9 (cytokine deficiency colitis susceptibility 9) interval centered near 71 cM. Moreover, C57BL/6J animals are known to carry the frameshift mutation Pla2g2a resulting in multiple intestinal neoplasia. The human ortholog PLA2G2A maps near a irritable bowel disorder (IBD) susceptibility locus named IBD7. Gnb1 (79.4 cM) also maps to the Cdcs9 QTL interval and is upregulated 2- to 5-fold in C57BL/6J-Il10 animals. Errfi1 (formerly 1300002F13Rik) and Tceb3 also map to the Cdcs9 interval and are upregulated 1.5- to 2-fold in C57BL/6J-Il10 animals. Areg (51 cM) on mouse Chromosome 5 maps near the Cdcs10 QTL interval centered around 45 cM. This candidate gene is upregulated 1.5- to 2-fold in C57BL/6J-Il10 animals. Mtmr7 maps to mouse Chromosome 8 near the Cdcs4 interval centered around 21 cM. This candidate gene is upregulated over 15-fold in C57BL/6J-Il10 animals. Cd14 (31 cM) on mouse Chromosome 18 is upregulated 5- to 15-fold in C3H/HeJBir-Il10 animals. CD14 also exhibits expression differences in parental wild type strains C3H/HeJBir and C57BL/6J. This candidate gene maps to the Cdcs6 (cytokine deficiency colitis susceptibility 6) interval centered near 41 cM. The human ortholog CD14 maps near a human irritable bowel disorder (IBD) susceptibility locus named IBD5. Glo1 (16 cM) and Ly6g6c on mouse Chromosome 17 are upregulated 2- to 5-fold in C57BL/6J-Il10 animals. This candidate gene maps to the Cdcs5 (cytokine deficiency colitis susceptibility 5) interval centered near 19 cM. Hspa1a (18.9 cM) and Hspa1b (18.9 cM) also map to Cdcs5 and are upregulated 1.5- to 2-fold in C57BL/6J-Il10 animals.

*cM position of peak correlated region/marker

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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