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Prss51 Gene Detail
Summary
  • Symbol
    Prss51
  • Name
    serine protease 51
  • Synonyms
    1700007N14Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921465
    NCBI Gene: 100504162
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:64323683-64335127 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 33.35 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    402 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921465
 protein coding gene Chr14:64322974-64335127 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021470
 protein coding gene Chr14:58650839-58662183 (+)
A/J MGP_AJ_G0021429
 protein coding gene Chr14:57300626-57312875 (+)
AKR/J MGP_AKRJ_G0021405
 protein coding gene Chr14:59327482-59340786 (+)
BALB/cJ MGP_BALBcJ_G0021435
 protein coding gene Chr14:57258122-57269479 (+)
C3H/HeJ MGP_C3HHeJ_G0021212
 protein coding gene Chr14:58954146-58965490 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021874
 protein coding gene Chr14:61389539-61400923 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019414
 protein coding gene Chr14:55235936-55246787 (+)
CAST/EiJ MGP_CASTEiJ_G0020729
 protein coding gene Chr14:55412841-55424310 (+)
CBA/J MGP_CBAJ_G0021179
 protein coding gene Chr14:63247555-63260989 (+)
DBA/2J MGP_DBA2J_G0021302
 protein coding gene Chr14:56975634-56987002 (+)
FVB/NJ MGP_FVBNJ_G0021281
 protein coding gene Chr14:56364234-56375615 (+)
LP/J MGP_LPJ_G0021377
 protein coding gene Chr14:59684492-59695818 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021310
 protein coding gene Chr14:62425498-62442387 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021897
 protein coding gene Chr14:58490634-58502027 (+)
PWK/PhJ MGP_PWKPhJ_G0020473
 protein coding gene Chr14:53651197-53662516 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020306
 protein coding gene Chr14:54452654-54464076 (+)
WSB/EiJ MGP_WSBEiJ_G0020782
 protein coding gene Chr14:58805522-58816897 (+)



Homology
more
  • Human Ortholog
    PRSS51, serine protease 51
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRSS51, serine protease 51
  • Links
    NCBI Gene ID: 346702
    UniProt: A0A1B0GVH4

  • Chr Location
    8p23.1; chr8:10481293-10547723 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    6 phenotype references
Mice homozygous for a null allele exhibit normal male fertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    4
  • GO References
    1
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000052099 Ensembl Gene Model | MGI Sequence Detail 11445 C57BL/6J ±  kb
transcript ENSMUST00000224112 Ensembl | MGI Sequence Detail 1042 Not Applicable  
polypeptide ENSMUSP00000153617 Ensembl | MGI Sequence Detail 319 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    4 Sequences
  • InterPro Domains
    IPR001314 Peptidase S1A, chymotrypsin family
    IPR009003 Peptidase S1, PA clan
    IPR043504 Peptidase S1, PA clan, chymotrypsin-like fold
    IPR001254 Serine proteases, trypsin domain
    IPR018114 Serine proteases, trypsin family, histidine active site
Molecular
Reagents
less
  • All nucleic 4
    cDNA 4

    Microarray probesets 3
References
more
  • Summaries
    All 23
    Gene Ontology 1
    Phenotypes 6
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:293896 Kobayashi K, et al., Prss55 but not Prss51 is required for male fertility in mice. Biol Reprod. 2020 Aug 4;103(2):223-234
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory