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Osbp2 Gene Detail
Summary
  • Symbol
    Osbp2
  • Name
    oxysterol binding protein 2
  • Synonyms
    1700095P05Rik, C630001G20Rik, ORP-4, OSBPL1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921559
    NCBI Gene: 74309
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:3653731-3813903 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 2.60 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3830 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921559
 protein coding gene Chr11:3653731-3814000 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017963
 protein coding gene Chr11:594276-759334 (-)
A/J MGP_AJ_G0017936
 protein coding gene Chr11:631392-794451 (-)
AKR/J MGP_AKRJ_G0017900
 protein coding gene Chr11:649701-820266 (-)
BALB/cJ MGP_BALBcJ_G0017904
 protein coding gene Chr11:595948-761305 (-)
C3H/HeJ MGP_C3HHeJ_G0017717
 protein coding gene Chr11:581796-747425 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018357
 protein coding gene Chr11:667979-839183 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016016
 protein coding gene Chr11:533912-694121 (-)
CAST/EiJ MGP_CASTEiJ_G0017279
 protein coding gene Chr11:549586-721035 (-)
CBA/J MGP_CBAJ_G0017692
 protein coding gene Chr11:839990-1032002 (-)
DBA/2J MGP_DBA2J_G0017803
 protein coding gene Chr11:542048-702958 (-)
FVB/NJ MGP_FVBNJ_G0017794
 protein coding gene Chr11:573850-739679 (-)
LP/J MGP_LPJ_G0017873
 protein coding gene Chr11:682464-851362 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017820
 protein coding gene Chr11:589443-754236 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018396
 protein coding gene Chr11:666573-837938 (-)
PWK/PhJ MGP_PWKPhJ_G0017060
 protein coding gene Chr11:531408-695369 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016856
 protein coding gene Chr11:623132-793154 (-)
WSB/EiJ MGP_WSBEiJ_G0017333
 protein coding gene Chr11:540670-711006 (-)



Homology
more
  • Human Ortholog
    OSBP2, oxysterol binding protein 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    OSBP2, oxysterol binding protein 2
  • Synonyms
    HLM, ORP-4, ORP4, OSBPL1, OSBPL4
  • Links
    NCBI Gene ID: 23762
    neXtProt AC: NX_Q969R2
    UniProt: Q969R2

  • Chr Location
    22q12.2; chr22:30693782-30907824 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 1 allele in 1 genetic background
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit male infertility with sperm defects including oligozoospermia, teratozoospermia, asthenozoospermia and abnormal spermiogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    720
  • Tissues
    13
  • cDNA Data
    45
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020435 Ensembl Gene Model | MGI Sequence Detail 160173 C57BL/6J ±  kb
    transcript ENSMUST00000070552 Ensembl | MGI Sequence Detail 4097 Not Applicable  
    polypeptide ENSMUSP00000068652 Ensembl | MGI Sequence Detail 908 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 46
      cDNA 45
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2685090
    References
    more
    • Summaries
      All 30
      Developmental Gene Expression 1
      Gene Ontology 7
      Phenotypes 3
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:351297 Ge T, et al., Coiled-coil domain containing 159 is required for spermatid head and tail assembly in mice. Biol Reprod. 2024 May 9;110(5):877-894
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory