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Rmi1 Gene Detail
Summary
  • Symbol
    Rmi1
  • Name
    RecQ mediated genome instability 1
  • Synonyms
    4932432N11Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921636
    NCBI Gene: 74386
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:58550062-58558962 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 31.05 cM, cytoband B2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    262 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921636
 protein coding gene Chr13:58550062-58558963 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020634
 protein coding gene Chr13:58042763-58051324 (+)
A/J MGP_AJ_G0020588
 protein coding gene Chr13:55889670-55898228 (+)
AKR/J MGP_AKRJ_G0020566
 protein coding gene Chr13:57551940-57560492 (+)
BALB/cJ MGP_BALBcJ_G0020584
 protein coding gene Chr13:56148248-56156762 (+)
C3H/HeJ MGP_C3HHeJ_G0020383
 protein coding gene Chr13:57359367-57368090 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021018
 protein coding gene Chr13:59825330-59833883 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018600
 protein coding gene Chr13:53781318-53789575 (+)
CAST/EiJ MGP_CASTEiJ_G0019897
 protein coding gene Chr13:57492382-57503729 (+)
CBA/J MGP_CBAJ_G0020343
 protein coding gene Chr13:62074480-62083037 (+)
DBA/2J MGP_DBA2J_G0020466
 protein coding gene Chr13:55439524-55448075 (+)
FVB/NJ MGP_FVBNJ_G0020445
 protein coding gene Chr13:54916512-54925156 (+)
LP/J MGP_LPJ_G0020542
 protein coding gene Chr13:58314543-58323075 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020474
 protein coding gene Chr13:61433981-61442533 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021061
 protein coding gene Chr13:57155914-57168463 (+)
PWK/PhJ MGP_PWKPhJ_G0019653
 protein coding gene Chr13:55447393-55456194 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019480
 protein coding gene Chr13:56065286-56073917 (+)
WSB/EiJ MGP_WSBEiJ_G0019959
 protein coding gene Chr13:57589100-57599502 (+)



Homology
more
  • Human Ortholog
    RMI1, RecQ mediated genome instability 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RMI1, RecQ mediated genome instability 1
  • Synonyms
    BLAP75, C9orf76, FAAP75
  • Links
    NCBI Gene ID: 80010
    neXtProt AC: NX_Q9H9A7
    UniProt: Q9H9A7

  • Chr Location
    9q21.32; chr9:83980359-84004074 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    8 phenotypes from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele exhibit decreased weight and increased resistance to diet-induced obesity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    711
  • Tissues
    1
  • cDNA Data
    48
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000035367 Ensembl Gene Model | MGI Sequence Detail 8901 C57BL/6J ±  kb
    transcript ENSMUST00000224479 Ensembl | MGI Sequence Detail 4212 Not Applicable  
    polypeptide ENSMUSP00000153050 Ensembl | MGI Sequence Detail 616 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000014036 RecQ-mediated genome instability protein 1
      (term hierarchy)
    • InterPro Domains
      IPR032199 RecQ-mediated genome instability protein 1, C-terminal OB-fold domain
      IPR044881 RecQ-mediated genome instability protein 1, N-terminal helical domain superfamily
      IPR013894 RecQ mediated genome instability protein 1, OB-fold domain
      IPR042470 RecQ mediated genome instability protein, N-terminal OB-fold domain superfamily
      IPR049363 RMI1, N-terminal domain
    • GlyGen
      Q9D4G9 2 sites, 2 N-linked glycans (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 49
      cDNA 48
      Primer pair 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2145511
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 1
      Gene Ontology 8
      Phenotypes 10
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:319969 Xue X, et al., Role of replication protein A in double holliday junction dissolution mediated by the BLM-Topo IIIalpha-RMI1-RMI2 protein complex. J Biol Chem. 2013 May 17;288(20):14221-14227
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory