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Odad4 Gene Detail
Summary
  • Symbol
    Odad4
  • Name
    outer dynein arm complex subunit 4
  • Synonyms
    4933404O19Rik, Ttc25
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921657
    NCBI Gene: 74407
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:100436434-100463392 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 63.47 cM, cytoband D
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    720 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921657
 protein coding gene Chr11:100436433-100463394 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019159
 protein coding gene Chr11:103306729-103333507 (+)
A/J MGP_AJ_G0019127
 protein coding gene Chr11:98995646-99023400 (+)
AKR/J MGP_AKRJ_G0019096
 protein coding gene Chr11:102055212-102083969 (+)
BALB/cJ MGP_BALBcJ_G0019101
 protein coding gene Chr11:99475234-99505690 (+)
C3H/HeJ MGP_C3HHeJ_G0018910
 protein coding gene Chr11:102241467-102270359 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019550
 protein coding gene Chr11:106520026-106551139 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017176
 protein coding gene Chr11:96415172-96442608 (+)
CAST/EiJ MGP_CASTEiJ_G0018464
 protein coding gene Chr11:103220137-103247021 (+)
CBA/J MGP_CBAJ_G0018879
 protein coding gene Chr11:110949419-110982776 (+)
DBA/2J MGP_DBA2J_G0018991
 protein coding gene Chr11:98534048-98560198 (+)
FVB/NJ MGP_FVBNJ_G0018981
 protein coding gene Chr11:98068355-98095811 (+)
LP/J MGP_LPJ_G0019060
 protein coding gene Chr11:103861220-103897429 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019012
 protein coding gene Chr11:110553539-110585703 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019588
 protein coding gene Chr11:102388888-102491772 (+)
PWK/PhJ MGP_PWKPhJ_G0018227
 protein coding gene Chr11:99573280-99600173 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018019
 protein coding gene Chr11:102123884-102152949 (+)
WSB/EiJ MGP_WSBEiJ_G0018513
 protein coding gene Chr11:102373260-102401433 (+)



Homology
more
  • Human Ortholog
    ODAD4, outer dynein arm docking complex subunit 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ODAD4, outer dynein arm docking complex subunit 4
  • Synonyms
    TTC25
  • Links
    NCBI Gene ID: 83538
    neXtProt AC: NX_Q96NG3
    UniProt: Q96NG3

  • Chr Location
    17q21.2; chr17:41930617-41966503 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Odad4 mouse models; 1 with human ODAD4 associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display partial preweaning lethality, impaired ciliary motility, and a variety of left-right body symmetry defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    7
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    707
  • Tissues
    1
  • cDNA Data
    22
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 74407 NCBI Gene Model | MGI Sequence Detail 26959 C57BL/6J ±  kb
    transcript NM_028918 RefSeq | MGI Sequence Detail 2842 C57BL/6  
    polypeptide Q9D4B2 UniProt | EBI | MGI Sequence Detail 624 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000029833 outer dynein arm-docking complex subunit 4
      (term hierarchy)
    • InterPro Domains
      IPR045135 26S proteasome regulatory subunit Rpn7, N-terminal
      IPR040111 Outer dynein arm-docking complex subunit 4
      IPR011990 Tetratricopeptide-like helical domain superfamily
      IPR019734 Tetratricopeptide repeat
    Molecular
    Reagents
    less
    • All nucleic 23
      cDNA 22
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:6459977
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 7
      Phenotypes 14
    • Earliest
      J:50799 Liu P, et al., Embryonic lethality and tumorigenesis caused by segmental aneuploidy on mouse chromosome 11. Genetics. 1998 Nov;150(3):1155-68
    • Latest
      J:301033 Ide T, et al., CFAP53 regulates mammalian cilia-type motility patterns through differential localization and recruitment of axonemal dynein components. PLoS Genet. 2020 Dec;16(12):e1009232
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory