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P4htm Gene Detail
Summary
  • Symbol
    P4htm
  • Name
    prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
  • Synonyms
    4933406E20Rik, P4h-tm
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921693
    NCBI Gene: 74443
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:108456061-108474866 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 59.52 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    506 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921693
 protein coding gene Chr9:108456025-108475482 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035308
 protein coding gene Chr9:110546225-110566654 (-)
A/J MGP_AJ_G0035287
 protein coding gene Chr9:106495090-106513054 (-)
AKR/J MGP_AKRJ_G0035219
 protein coding gene Chr9:109164184-109188094 (-)
BALB/cJ MGP_BALBcJ_G0035281
 protein coding gene Chr9:106190554-106210545 (-)
C3H/HeJ MGP_C3HHeJ_G0034991
 protein coding gene Chr9:109565532-109585491 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035801
 protein coding gene Chr9:113560911-113580443 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032699
 protein coding gene Chr9:103923279-103942447 (-)
CAST/EiJ MGP_CASTEiJ_G0034302
 protein coding gene Chr9:109523529-109546888 (-)
CBA/J MGP_CBAJ_G0034959
 protein coding gene Chr9:117567097-117586653 (-)
DBA/2J MGP_DBA2J_G0035120
 protein coding gene Chr9:105954055-105972162 (-)
FVB/NJ MGP_FVBNJ_G0035068
 protein coding gene Chr9:104715722-104737751 (-)
LP/J MGP_LPJ_G0035196
 protein coding gene Chr9:110740802-110760970 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035107
 protein coding gene Chr9:119139207-119159690 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035822
 protein coding gene Chr9:109442979-109462855 (-)
PWK/PhJ MGP_PWKPhJ_G0034009
 protein coding gene Chr9:106279535-106298500 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033844
 protein coding gene Chr9:109505667-109526254 (-)
WSB/EiJ MGP_WSBEiJ_G0034423
 protein coding gene Chr9:109324716-109345172 (-)



Homology
more
  • Human Ortholog
    P4HTM, prolyl 4-hydroxylase, transmembrane
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    P4HTM, prolyl 4-hydroxylase, transmembrane
  • Synonyms
    EGLN4, HIDEA, HIFPH4, P4H-TM, PH-4, PH4, PHD4
  • Links
    NCBI Gene ID: 54681
    neXtProt AC: NX_Q9NXG6
    UniProt: Q9NXG6

  • Chr Location
    3p21.31; chr3:48989889-49007153 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    3 phenotypes from multigenic genotypes
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit decreased body weight, normal erythropoiesis, and cardioprotection after ischemia-reperfusion injury.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    709
  • Tissues
    3
  • cDNA Data
    13
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000006675 Ensembl Gene Model | MGI Sequence Detail 18806 C57BL/6J ±  kb
    transcript ENSMUST00000006853 Ensembl | MGI Sequence Detail 1841 Not Applicable  
    polypeptide ENSMUSP00000006853 Ensembl | MGI Sequence Detail 503 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 13
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2143159, MGI:2143365
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 1
      Gene Ontology 8
      Phenotypes 9
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:313923 Byts N, et al., Transmembrane Prolyl 4-Hydroxylase is a Novel Regulator of Calcium Signaling in Astrocytes. eNeuro. 2021 Jan-Feb;8(1):ENEURO.0253-20.2020
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory