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Lrrc17 Gene Detail
Summary
  • Symbol
    Lrrc17
  • Name
    leucine rich repeat containing 17
  • Synonyms
    37kDa, 4833425M04Rik, 6130400C22Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921761
    NCBI Gene: 74511
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:21748557-21780902 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 9.89 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1123 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921761
 protein coding gene Chr5:21748525-21780909 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029319
 protein coding gene Chr5:19097803-19129698 (+)
A/J MGP_AJ_G0029284
 protein coding gene Chr5:18480950-18514235 (+)
AKR/J MGP_AKRJ_G0029235
 protein coding gene Chr5:19183089-19215371 (+)
BALB/cJ MGP_BALBcJ_G0029296
 protein coding gene Chr5:18918561-18952334 (+)
C3H/HeJ MGP_C3HHeJ_G0029015
 protein coding gene Chr5:19253451-19287812 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029749
 protein coding gene Chr5:20504504-20538354 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026988
 protein coding gene Chr5:16538501-16570599 (+)
CAST/EiJ MGP_CASTEiJ_G0028427
 protein coding gene Chr5:18576537-18614105 (+)
CBA/J MGP_CBAJ_G0028982
 protein coding gene Chr5:20714255-20751595 (+)
DBA/2J MGP_DBA2J_G0029134
 protein coding gene Chr5:18765109-18797725 (+)
FVB/NJ MGP_FVBNJ_G0029092
 protein coding gene Chr5:18171525-18205493 (+)
LP/J MGP_LPJ_G0029218
 protein coding gene Chr5:19512285-19544216 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029120
 protein coding gene Chr5:22013765-22046065 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029782
 protein coding gene Chr5:18845119-18878890 (+)
PWK/PhJ MGP_PWKPhJ_G0028150
 protein coding gene Chr5:17813331-17845574 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027983
 protein coding gene Chr5:18205178-18241850 (+)
WSB/EiJ MGP_WSBEiJ_G0028507
 protein coding gene Chr5:18904374-18937486 (+)



Homology
more
  • Human Ortholog
    LRRC17, leucine rich repeat containing 17
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LRRC17, leucine rich repeat containing 17
  • Synonyms
    P37NB
  • Links
    NCBI Gene ID: 10234
    neXtProt AC: NX_Q8N6Y2
    UniProt: Q8N6Y2

  • Chr Location
    7q22.1; chr7:102913000-102945111 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 1 allele in 1 genetic background
    8 phenotypes from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted allele exhibit normal phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    2
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    737
  • Tissues
    17
  • cDNA Data
    49
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000039883 Ensembl Gene Model | MGI Sequence Detail 32346 C57BL/6J ±  kb
    transcript ENSMUST00000035651 Ensembl | MGI Sequence Detail 2154 Not Applicable  
    polypeptide ENSMUSP00000038569 Ensembl | MGI Sequence Detail 443 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000032087 leucine-rich repeat-containing protein 17
      (term hierarchy)
    • InterPro Domains
      IPR000483 Cysteine-rich flanking region, C-terminal
      IPR001611 Leucine-rich repeat
      IPR050541 Leucine-rich repeat and transmembrane domain-containing protein
      IPR032675 Leucine-rich repeat domain superfamily
      IPR003591 Leucine-rich repeat, typical subtype
    Molecular
    Reagents
    less
    • All nucleic 54
      Genomic 1
      cDNA 50
      Primer pair 2
      Other 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:1921859
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 2
      Phenotypes 15
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory