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Wdr35 Gene Detail
Summary
  • Symbol
    Wdr35
  • Name
    WD repeat domain 35
  • Synonyms
    4930459M12Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921932
    NCBI Gene: 74682
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:9023897-9078848 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 3.97 cM, cytoband A1.3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1326 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921932
 protein coding gene Chr12:9023892-9078848 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019591
 protein coding gene Chr12:6062037-6119998 (+)
A/J MGP_AJ_G0019558
 protein coding gene Chr12:5885389-5943061 (+)
AKR/J MGP_AKRJ_G0019528
 protein coding gene Chr12:6275668-6336187 (+)
BALB/cJ MGP_BALBcJ_G0019533
 protein coding gene Chr12:6015928-6071448 (+)
C3H/HeJ MGP_C3HHeJ_G0019339
 protein coding gene Chr12:6109685-6168038 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019982
 protein coding gene Chr12:6248382-6309450 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017607
 protein coding gene Chr12:5692036-5747094 (+)
CAST/EiJ MGP_CASTEiJ_G0018894
 protein coding gene Chr12:6100566-6156155 (+)
CBA/J MGP_CBAJ_G0019310
 protein coding gene Chr12:6796711-6856500 (+)
DBA/2J MGP_DBA2J_G0019423
 protein coding gene Chr12:5834835-5891748 (+)
FVB/NJ MGP_FVBNJ_G0019414
 protein coding gene Chr12:5811209-5867338 (+)
LP/J MGP_LPJ_G0019494
 protein coding gene Chr12:6114885-6174614 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019447
 protein coding gene Chr12:6596453-6653488 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020021
 protein coding gene Chr12:6023794-6080793 (+)
PWK/PhJ MGP_PWKPhJ_G0018660
 protein coding gene Chr12:5903808-5960750 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018451
 protein coding gene Chr12:6026031-6091636 (+)
WSB/EiJ MGP_WSBEiJ_G0018945
 protein coding gene Chr12:6077592-6136249 (+)



Homology
more
  • Human Ortholog
    WDR35, WD repeat domain 35
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    WDR35, WD repeat domain 35
  • Synonyms
    CED2, CFAP118, FAP118, IFT121, IFTA1, SRTD7
  • Links
    NCBI Gene ID: 57539
    neXtProt AC: NX_Q9P2L0
    UniProt: Q9P2L0

  • Chr Location
    2p24.1; chr2:19910263-19990105 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Wdr35 mouse models; 3 with human WDR35 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 3 alleles in 3 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU induced mutation exhibit mid-gestation lethality, heart development defects, turning defects, polysyndactyly, hypoplastic lungs, tracheoesophageal fistula, herniated diaphragm and absent embryonic cilia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    758
  • Tissues
    12
  • cDNA Data
    64
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 74682 NCBI Gene Model | MGI Sequence Detail 54952 C57BL/6J ±  kb
    transcript NM_172470 RefSeq | MGI Sequence Detail 4409 C57BL/6  
    polypeptide Q8BND3 UniProt | EBI | MGI Sequence Detail 1181 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 73
      cDNA 66
      Primer pair 7

      Microarray probesets 4
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 11
      Phenotypes 7
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:281311 Nakano Y, et al., Overlapping Activities of Two Neuronal Splicing Factors Switch the GABA Effect from Excitatory to Inhibitory by Regulating REST. Cell Rep. 2019 Apr 16;27(3):860-871.e8
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory