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Ddit4 Gene Detail
Summary
  • Symbol
    Ddit4
  • Name
    DNA-damage-inducible transcript 4
  • Synonyms
    5830413E08Rik, Dig2, REDD1, Rtp801
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921997
    NCBI Gene: 74747
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:59785497-59787592 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 29.66 cM, cytoband B3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    67 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921997
 protein coding gene Chr10:59785491-59787656 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017262
 protein coding gene Chr10:59145830-59147925 (-)
A/J MGP_AJ_G0017240
 protein coding gene Chr10:57413278-57415373 (-)
AKR/J MGP_AKRJ_G0017200
 protein coding gene Chr10:58904248-58906343 (-)
BALB/cJ MGP_BALBcJ_G0017200
 protein coding gene Chr10:57503182-57505277 (-)
C3H/HeJ MGP_C3HHeJ_G0017023
 protein coding gene Chr10:58824979-58827074 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017658
 protein coding gene Chr10:61263772-61265867 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015349
 protein coding gene Chr10:54430040-54432126 (-)
CAST/EiJ MGP_CASTEiJ_G0016594
 protein coding gene Chr10:58755902-58757988 (-)
CBA/J MGP_CBAJ_G0016995
 protein coding gene Chr10:63451895-63453990 (-)
DBA/2J MGP_DBA2J_G0017100
 protein coding gene Chr10:56723337-56725432 (-)
FVB/NJ MGP_FVBNJ_G0017094
 protein coding gene Chr10:55958379-55960474 (-)
LP/J MGP_LPJ_G0017175
 protein coding gene Chr10:59519007-59521102 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017122
 protein coding gene Chr10:65954600-65956695 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017696
 protein coding gene Chr10:58713967-58716062 (-)
PWK/PhJ MGP_PWKPhJ_G0016377
 protein coding gene Chr10:56526943-56529029 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016160
 protein coding gene Chr10:58043025-58045112 (-)
WSB/EiJ MGP_WSBEiJ_G0016658
 protein coding gene Chr10:58618817-58620912 (-)



Homology
more
  • Human Ortholog
    DDIT4, DNA damage inducible transcript 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DDIT4, DNA damage inducible transcript 4
  • Synonyms
    Dig2, REDD-1, REDD1
  • Links
    NCBI Gene ID: 54541
    neXtProt AC: NX_Q9NX09
    UniProt: Q9NX09

  • Chr Location
    10q22.1; chr10:72273919-72276036 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 4 alleles in 4 genetic backgrounds
    52 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice show resistance to hyperoxia-induced retinopathy. Mice homozygous for another knock-out allele exhibit normal testis development and fertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    33
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    742
  • Tissues
    23
  • cDNA Data
    100
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 74747 NCBI Gene Model | MGI Sequence Detail 2096 C57BL/6J ±  kb
    transcript NM_029083 RefSeq | MGI Sequence Detail 1685 C57BL/6  
    polypeptide Q9D3F7 UniProt | EBI | MGI Sequence Detail 229 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 105
      Genomic 2
      cDNA 101
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2143476
    References
    more
    • Summaries
      All 104
      Developmental Gene Expression 11
      Gene Ontology 10
      Phenotypes 52
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:341688 Xie X, et al., SRSF2 in Sertoli cells is essential for testicular development and spermatogenesis in mice. FASEB J. 2023 May;37(5):e22918
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory