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Mss51 Gene Detail
Summary
  • Symbol
    Mss51
  • Name
    MSS51 mitochondrial translational activator
  • Synonyms
    4833444M15Rik, Zmynd17
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922093
    NCBI Gene: 74843
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:20532935-20546969 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 11.53 cM, cytoband B
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    353 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1922093
 protein coding gene Chr14:20532925-20546969 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021037
 protein coding gene Chr14:13243544-13257488 (-)
A/J MGP_AJ_G0020986
 protein coding gene Chr14:12936382-12950306 (-)
AKR/J MGP_AKRJ_G0020963
 protein coding gene Chr14:13458378-13475200 (-)
BALB/cJ MGP_BALBcJ_G0020989
 protein coding gene Chr14:13039907-13054268 (-)
C3H/HeJ MGP_C3HHeJ_G0020773
 protein coding gene Chr14:13397188-13412182 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021422
 protein coding gene Chr14:13738028-13754422 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018990
 protein coding gene Chr14:13247191-13261029 (-)
CAST/EiJ MGP_CASTEiJ_G0020297
 protein coding gene Chr14:13157842-13172925 (-)
CBA/J MGP_CBAJ_G0020739
 protein coding gene Chr14:14439963-14453936 (-)
DBA/2J MGP_DBA2J_G0020862
 protein coding gene Chr14:12762236-12776128 (-)
FVB/NJ MGP_FVBNJ_G0020845
 protein coding gene Chr14:12656384-12670263 (-)
LP/J MGP_LPJ_G0020938
 protein coding gene Chr14:13467010-13480774 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020871
 protein coding gene Chr14:14208551-14224494 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021455
 protein coding gene Chr14:13248649-13262844 (-)
PWK/PhJ MGP_PWKPhJ_G0020046
 protein coding gene Chr14:12324501-12341930 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019868
 protein coding gene Chr14:13029087-13044710 (-)
WSB/EiJ MGP_WSBEiJ_G0020353
 protein coding gene Chr14:13229705-13245050 (-)



Homology
more
  • Human Ortholog
    MSS51, MSS51 mitochondrial translational activator
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MSS51, MSS51 mitochondrial translational activator
  • Synonyms
    ZMYND17
  • Links
    NCBI Gene ID: 118490
    neXtProt AC: NX_Q4VC12
    UniProt: Q4VC12

  • Chr Location
    10q22.2; chr10:73423579-73433561 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit glucose intolerance, insulin resistance, and hepatic steatosis when fed a high-fat diet. Muscle shows mitochondrial abnormalities and mice show decreased running performance.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    1
  • GO References
    1
Molecular Function

Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021815 Ensembl Gene Model | MGI Sequence Detail 14035 C57BL/6J ±  kb
    transcript ENSMUST00000022353 Ensembl | MGI Sequence Detail 1826 Not Applicable  
    polypeptide ENSMUSP00000022353 Ensembl | MGI Sequence Detail 446 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000030483 putative protein MSS51 homolog, mitochondrial
      (term hierarchy)
    • InterPro Domains
      IPR052839 Mitochondrial gene expression regulator
      IPR046824 Mitochondrial splicing suppressor 51-like, C-terminal domain
      IPR002893 Zinc finger, MYND-type
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 8

      Microarray probesets 2
    References
    more
    • Summaries
      All 26
      Gene Ontology 1
      Phenotypes 5
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:335360 Mousa MG, et al., Site-1 protease inhibits mitochondrial respiration by controlling the TGF-beta target gene Mss51. Cell Rep. 2023 Mar 31;42(4):112336
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory