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Sv2c Gene Detail
Summary
  • Symbol
    Sv2c
  • Name
    synaptic vesicle glycoprotein 2c
  • Synonyms
    4930527L09Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922459
    NCBI Gene: 75209
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:96091102-96269085 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 50.47 cM, cytoband D1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    6362 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1922459
 protein coding gene Chr13:96091102-96270837 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020846
 protein coding gene Chr13:97456301-97640404 (-)
A/J MGP_AJ_G0020800
 protein coding gene Chr13:93797292-93974190 (-)
AKR/J MGP_AKRJ_G0020774
 protein coding gene Chr13:96660802-96850924 (-)
BALB/cJ MGP_BALBcJ_G0020797
 protein coding gene Chr13:94476487-94656463 (-)
C3H/HeJ MGP_C3HHeJ_G0020590
 protein coding gene Chr13:96354073-96540907 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021233
 protein coding gene Chr13:100407054-100610992 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018802
 protein coding gene Chr13:89609917-89790573 (-)
CAST/EiJ MGP_CASTEiJ_G0020109
 protein coding gene Chr13:95661903-95849576 (-)
CBA/J MGP_CBAJ_G0020549
 protein coding gene Chr13:104386763-104580101 (-)
DBA/2J MGP_DBA2J_G0020674
 protein coding gene Chr13:93572140-93752801 (-)
FVB/NJ MGP_FVBNJ_G0020655
 protein coding gene Chr13:92353555-92532315 (-)
LP/J MGP_LPJ_G0020749
 protein coding gene Chr13:97573048-97777973 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020683
 protein coding gene Chr13:104815934-105007110 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021273
 protein coding gene Chr13:96064797-96261572 (-)
PWK/PhJ MGP_PWKPhJ_G0019861
 protein coding gene Chr13:92357099-92540291 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019685
 protein coding gene Chr13:92350362-92543403 (-)
WSB/EiJ MGP_WSBEiJ_G0020166
 protein coding gene Chr13:96563108-96749016 (-)



Homology
more
  • Human Ortholog
    SV2C, synaptic vesicle glycoprotein 2C
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SV2C, synaptic vesicle glycoprotein 2C
  • Synonyms
    SLC22B3
  • Links
    NCBI Gene ID: 22987
    neXtProt AC: NX_Q496J9
    UniProt: Q496J9

  • Chr Location
    5q13.3; chr5:75847464-76353939 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit hypoactivity and increased anxiety-related response.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    14
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    835
  • Tissues
    112
  • cDNA Data
    8
  • Literature Summary
    14
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000051111 Ensembl Gene Model | MGI Sequence Detail 177984 C57BL/6J ±  kb
transcript ENSMUST00000161263 Ensembl | MGI Sequence Detail 9101 Not Applicable  
polypeptide ENSMUSP00000124473 Ensembl | MGI Sequence Detail 727 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 9
    cDNA 8
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:2145291
References
more
  • Summaries
    All 55
    Developmental Gene Expression 14
    Gene Ontology 7
    Phenotypes 13
  • Earliest
    J:36947 Ahnert-Hilger G, et al., Synaptobrevin is essential for secretion but not for the development of synaptic processes. Eur J Cell Biol. 1996 May;70(1):1-11
  • Latest
    J:347652 Bucher ML, et al., Synaptic vesicle glycoprotein 2C enhances vesicular storage of dopamine and counters dopaminergic toxicity. Eur J Neurosci. 2024 Mar 26;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory