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Smlr1 Gene Detail
Summary
  • Symbol
    Smlr1
  • Name
    small leucine-rich protein 1
  • Synonyms
    2010003K15Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922856
    NCBI Gene: 100504474
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:25403841-25412165 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 12.26 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    463 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1922856
 protein coding gene Chr10:25403841-25412170 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017099
 protein coding gene Chr10:23561410-23569733 (-)
A/J MGP_AJ_G0017076
 protein coding gene Chr10:22846588-22855109 (-)
AKR/J MGP_AKRJ_G0017036
 protein coding gene Chr10:23229882-23238403 (-)
BALB/cJ MGP_BALBcJ_G0017039
 protein coding gene Chr10:22985498-22994019 (-)
C3H/HeJ MGP_C3HHeJ_G0016859
 protein coding gene Chr10:23448721-23457242 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017497
 protein coding gene Chr10:24292432-24300756 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015195
 protein coding gene Chr10:21514218-21523672 (-)
CAST/EiJ MGP_CASTEiJ_G0016438
 protein coding gene Chr10:23411534-23420144 (-)
CBA/J MGP_CBAJ_G0016833
 protein coding gene Chr10:25423371-25431695 (-)
DBA/2J MGP_DBA2J_G0016938
 protein coding gene Chr10:22579291-22587615 (-)
FVB/NJ MGP_FVBNJ_G0016933
 protein coding gene Chr10:22276828-22285349 (-)
LP/J MGP_LPJ_G0017015
 protein coding gene Chr10:23545454-23553777 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016963
 protein coding gene Chr10:25465111-25473619 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017533
 protein coding gene Chr10:23099539-23108045 (-)
PWK/PhJ MGP_PWKPhJ_G0016220
 protein coding gene Chr10:22379624-22388316 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016004
 protein coding gene Chr10:22919199-22927931 (-)
WSB/EiJ MGP_WSBEiJ_G0016501
 protein coding gene Chr10:23240994-23249511 (-)



Homology
more
  • Human Ortholog
    SMLR1, small leucine rich protein 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SMLR1, small leucine rich protein 1
  • Links
    NCBI Gene ID: 100507203
    neXtProt AC: NX_H3BR10
    UniProt: H3BR10

  • Chr Location
    chr6:130827406-130837135 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    2
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    1
  • Genomic Mutations
    1 involving Smlr1
  • Find Mice (IMSR)
    2 strains or lines available
Homozygous mice die before birth.
Gene Ontology
(GO)
Classifications
less
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000096546 Ensembl Gene Model | MGI Sequence Detail 8325 C57BL/6J ±  kb
transcript ENSMUST00000179685 Ensembl | MGI Sequence Detail 669 Not Applicable  
polypeptide ENSMUSP00000136316 Ensembl | MGI Sequence Detail 66 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
Molecular
Reagents
less
  • All nucleic 5
    cDNA 5

    Microarray probesets 2
Other
Accession IDs
less
MGI:2143779
References
more
  • Summaries
    All 23
    Phenotypes 6
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:344880 van Zwol W, et al., Loss of hepatic SMLR1 causes hepatosteatosis and protects against atherosclerosis due to decreased hepatic VLDL secretion. Hepatology. 2023 Nov 1;78(5):1418-1432
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory