Gns MGI Mouse Gene Detail - MGI:1922862 - glucosamine (N-acetyl)-6-sulfatase

Symbol

Gns
Name

glucosamine (N-acetyl)-6-sulfatase
Synonyms

2610016K11Rik, G6S

Feature Type

protein coding gene
IDs

MGI:1922862
NCBI Gene: 75612
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr10:121200995-121233154 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 69.62 cM
Mapping Data

2 experiments

SNPs within 2kb

1362 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1922862	protein coding gene	Chr10:121200995-121233159 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017781	protein coding gene	Chr10:124621675-124653589 (+)
A/J	MGP_AJ_G0017756	protein coding gene	Chr10:119661469-119693970 (+)
AKR/J	MGP_AKRJ_G0017719	protein coding gene	Chr10:123235048-123267189 (+)
BALB/cJ	MGP_BALBcJ_G0017720	protein coding gene	Chr10:120053957-120087139 (+)
C3H/HeJ	MGP_C3HHeJ_G0017544	protein coding gene	Chr10:123445631-123477775 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018175	protein coding gene	Chr10:128860148-128893770 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015855	protein coding gene	Chr10:113991599-114024795 (+)
CAST/EiJ	MGP_CASTEiJ_G0017104	protein coding gene	Chr10:123809259-123845961 (+)
CBA/J	MGP_CBAJ_G0017513	protein coding gene	Chr10:134103092-134139667 (+)
DBA/2J	MGP_DBA2J_G0017619	protein coding gene	Chr10:118786141-118819251 (+)
FVB/NJ	MGP_FVBNJ_G0017614	protein coding gene	Chr10:117769358-117801656 (+)
LP/J	MGP_LPJ_G0017693	protein coding gene	Chr10:125155373-125189171 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017643	protein coding gene	Chr10:136647510-136680013 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018215	protein coding gene	Chr10:123262156-123296407 (+)
PWK/PhJ	MGP_PWKPhJ_G0016889	protein coding gene	Chr10:118902996-118936040 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016680	protein coding gene	Chr10:122149793-122182909 (+)
WSB/EiJ	MGP_WSBEiJ_G0017165	protein coding gene	Chr10:123484359-123517757 (+)

Human Ortholog

GNS, glucosamine (N-acetyl)-6-sulfatase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GNS, glucosamine (N-acetyl)-6-sulfatase
Synonyms

G6S
Links

HGNC:4422

NCBI Gene ID: 2799

neXtProt AC: NX_P15586

UniProt: P15586
Chr Location

12q14.3; chr12:64713445-64759431 (-) GRCh38

MGI Vertebrate Homology

Gns stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: GNS
Protein SuperFamily

G6S
Gene Tree

Gns

Diseases

1 with Gns mouse models; 2 with human GNS associations

Human Disease

Mouse Models

mucopolysaccharidosis III

IDs

View 1 model

mucopolysaccharidosis type IIID

IDs

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

less

Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
5 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

1
Gene trapped

3
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

26 strains or lines available

Homozygous KO results in progressive lysosomal glycosaminoglycan accumulation in the central nervous system and peripheral organs and causes hypoactivity and shortened lifespan.

less

All GO Annotations

13
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

828
Tissues

114
cDNA Data

27
Literature Summary

5

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gns

less

All Sequences

127
RefSeq

4
UniProt

8
CCDS

CCDS24210.1

Ensembl

ENSMUSG00000034707 (Evidence)
NCBI Gene

75612

			Length	Strain/Species	Flank
genomic	ENSMUSG00000034707	Ensembl Gene Model \| MGI Sequence Detail	32160	C57BL/6J	± kb
transcript	ENSMUST00000040344	Ensembl \| MGI Sequence Detail	3855	Not Applicable
polypeptide	ENSMUSP00000043167	Ensembl \| MGI Sequence Detail	544	Not Applicable

less

UniProt

8 Sequences
Protein Ontology

PR:000008129 N-acetylglucosamine-6-sulfatase

(term hierarchy)
EC

3.1.6.14
InterPro Domains

IPR017850 Alkaline-phosphatase-like, core domain superfamily

IPR012251 N-acetylglucosamine-6-sulfatase

IPR032506 N-sulphoglucosamine sulphohydrolase, C-terminal

IPR024607 Sulfatase, conserved site

IPR000917 Sulfatase, N-terminal
GlyGen

Q8BFR4 13 sites, 11 N-linked glycans (7 sites), 1 O-linked glycan (1 site)

less

All nucleic 29

cDNA 27

Primer pair 1

Other 1

Microarray probesets 5

less

MGI:2143761, MGI:2143948, MGI:2143956

Summaries

All 38

Developmental Gene Expression 5

Diseases 1

Gene Ontology 7

Phenotypes 5
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034

TSS for Gns:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr96022	Chr10:121200983-121201063 (+)	28 bp
Tssr96023	Chr10:121205032-121205038 (+)	4,040 bp
Tssr96024	Chr10:121210255-121210273 (+)	9,269 bp
Tssr96025	Chr10:121210306-121210344 (+)	9,330 bp
Tssr96026	Chr10:121212127-121212150 (+)	11,144 bp
Tssr96027	Chr10:121212358-121212383 (+)	11,376 bp
Tssr96028	Chr10:121213091-121213120 (+)	12,111 bp
Tssr96029	Chr10:121217072-121217088 (+)	16,085 bp
Tssr96030	Chr10:121228706-121228719 (+)	27,718 bp
Tssr96031	Chr10:121231071-121231117 (+)	30,099 bp
Tssr96032	Chr10:121231156-121231178 (+)	30,172 bp
Tssr96033	Chr10:121231226-121231274 (+)	30,255 bp
Tssr96034	Chr10:121231741-121231776 (+)	30,764 bp
Tssr96035	Chr10:121232667-121232680 (+)	31,679 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24