About   Help   FAQ
Them4 Gene Detail
Summary
  • Symbol
    Them4
  • Name
    thioesterase superfamily member 4
  • Synonyms
    2700077M13Rik, 4921507I02Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923028
    NCBI Gene: 75778
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:94217415-94239847 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 40.51 cM, cytoband F2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    407 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923028
 protein coding gene Chr3:94217396-94239847 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027544
 protein coding gene Chr3:94875042-94900635 (+)
A/J MGP_AJ_G0027503
 protein coding gene Chr3:91989734-92014664 (+)
AKR/J MGP_AKRJ_G0027471
 protein coding gene Chr3:94076604-94102570 (+)
BALB/cJ MGP_BALBcJ_G0027514
 protein coding gene Chr3:91694933-91717486 (+)
C3H/HeJ MGP_C3HHeJ_G0027250
 protein coding gene Chr3:94372737-94395084 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027963
 protein coding gene Chr3:98472478-98495933 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025305
 protein coding gene Chr3:88478340-88502512 (+)
CAST/EiJ MGP_CASTEiJ_G0026698
 protein coding gene Chr3:93719786-93743812 (+)
CBA/J MGP_CBAJ_G0027226
 protein coding gene Chr3:101965447-101987743 (+)
DBA/2J MGP_DBA2J_G0027365
 protein coding gene Chr3:91248296-91275147 (+)
FVB/NJ MGP_FVBNJ_G0027335
 protein coding gene Chr3:89352122-89379578 (+)
LP/J MGP_LPJ_G0027473
 protein coding gene Chr3:96187618-96209906 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027362
 protein coding gene Chr3:108192760-108218273 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028017
 protein coding gene Chr3:93762518-93787415 (+)
PWK/PhJ MGP_PWKPhJ_G0026426
 protein coding gene Chr3:91142911-91166351 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026247
 protein coding gene Chr3:92105162-92128129 (+)
WSB/EiJ MGP_WSBEiJ_G0026781
 protein coding gene Chr3:94111351-94134710 (+)



Homology
more
  • Human Ortholog
    THEM4, thioesterase superfamily member 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    THEM4, thioesterase superfamily member 4
  • Synonyms
    CTMP
  • Links
    NCBI Gene ID: 117145
    neXtProt AC: NX_Q5T1C6
    UniProt: Q5T1C6

  • Chr Location
    1q21.3; chr1:151870866-151909637 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    2 images
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit elongated mitochondria.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    759
  • Tissues
    12
  • cDNA Data
    41
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 75778 NCBI Gene Model | MGI Sequence Detail 22433 C57BL/6J ±  kb
transcript NM_029431 RefSeq | MGI Sequence Detail 1706 C57BL/6  
polypeptide Q3UUI3 UniProt | EBI | MGI Sequence Detail 230 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 41
    cDNA 41

    Microarray probesets 5
Other
Accession IDs
less
MGI:1919874
References
more
  • Summaries
    All 35
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 4
    Phenotypes 10
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:344584 Wang J, et al., Carboxyl-terminal modulator protein (CTMP) deficiency mitigates denervation-induced skeletal muscle atrophy. Biochem Biophys Res Commun. 2023 Feb 12;644:155-161
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory