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Ppp1r14c Gene Detail
Summary
  • Symbol
    Ppp1r14c
  • Name
    protein phosphatase 1, regulatory inhibitor subunit 14C
  • Synonyms
    6330514J04Rik, KEPI
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923392
    NCBI Gene: 76142
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:3316057-3414975 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 2.06 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    2280 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923392
 protein coding gene Chr10:3315974-3414975 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016972
 protein coding gene Chr10:279742-388069 (+)
A/J MGP_AJ_G0016950
 protein coding gene Chr10:270951-370411 (+)
AKR/J MGP_AKRJ_G0016915
 protein coding gene Chr10:236634-348678 (+)
BALB/cJ MGP_BALBcJ_G0016908
 protein coding gene Chr10:241631-345056 (+)
C3H/HeJ MGP_C3HHeJ_G0016733
 protein coding gene Chr10:300201-402630 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017371
 protein coding gene Chr10:260581-369937 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015077
 protein coding gene Chr10:147468-240944 (+)
CAST/EiJ MGP_CASTEiJ_G0016315
 protein coding gene Chr10:334854-440471 (+)
CBA/J no annotation
DBA/2J MGP_DBA2J_G0016813
 protein coding gene Chr10:290020-390788 (+)
FVB/NJ MGP_FVBNJ_G0016808
 protein coding gene Chr10:237739-341638 (+)
LP/J MGP_LPJ_G0016888
 protein coding gene Chr10:283960-398511 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016839
 protein coding gene Chr10:260893-368788 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017408
 protein coding gene Chr10:243125-347690 (+)
PWK/PhJ MGP_PWKPhJ_G0016101
 protein coding gene Chr10:283117-383602 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015882
 protein coding gene Chr10:446317-596222 (+)
WSB/EiJ MGP_WSBEiJ_G0016376
 protein coding gene Chr10:297122-403098 (+)



Homology
more
  • Human Ortholog
    PPP1R14C, protein phosphatase 1 regulatory inhibitor subunit 14C
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PPP1R14C, protein phosphatase 1 regulatory inhibitor subunit 14C
  • Synonyms
    CPI17-like, KEPI, NY-BR-81
  • Links
    NCBI Gene ID: 81706
    neXtProt AC: NX_Q8TAE6
    UniProt: Q8TAE6

  • Chr Location
    6q25.1; chr6:150143044-150250392 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Ppp1r14c mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 2 genetic backgrounds
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit some prenatal lethality and enhanced behavioral response to morphine.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    710
  • Tissues
    3
  • cDNA Data
    31
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000040653 Ensembl Gene Model | MGI Sequence Detail 98919 C57BL/6J ±  kb
transcript ENSMUST00000043374 Ensembl | MGI Sequence Detail 2617 Not Applicable  
polypeptide ENSMUSP00000045110 Ensembl | MGI Sequence Detail 164 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 33
    cDNA 31
    Primer pair 2

    Microarray probesets 6
References
more
  • Summaries
    All 29
    Developmental Gene Expression 2
    Diseases 1
    Gene Ontology 5
    Phenotypes 3
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:308818 Moreau MX, et al., Single-cell transcriptomics of the early developing mouse cerebral cortex disentangle the spatial and temporal components of neuronal fate acquisition. Development. 2021 Jul 15;148(14):dev197962
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory