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Rars2 Gene Detail
Summary
  • Symbol
    Rars2
  • Name
    arginyl-tRNA synthetase 2, mitochondrial
  • Synonyms
    1500002I10Rik, PRO1992, Rarsl
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923596
    NCBI Gene: 109093
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:34614957-34660167 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 16.84 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1317 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923596
 protein coding gene Chr4:34614941-34660167 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028128
 protein coding gene Chr4:32200262-32245467 (+)
A/J MGP_AJ_G0028086
 protein coding gene Chr4:31031624-31076795 (+)
AKR/J MGP_AKRJ_G0028049
 protein coding gene Chr4:31842521-31887738 (+)
BALB/cJ MGP_BALBcJ_G0028097
 protein coding gene Chr4:31308858-31354065 (+)
C3H/HeJ MGP_C3HHeJ_G0027826
 protein coding gene Chr4:32158954-32204611 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028539
 protein coding gene Chr4:33429276-33475322 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025880
 protein coding gene Chr4:29145392-29189549 (+)
CAST/EiJ MGP_CASTEiJ_G0027281
 protein coding gene Chr4:31951167-31998029 (+)
CBA/J MGP_CBAJ_G0027798
 protein coding gene Chr4:34517866-34563057 (+)
DBA/2J MGP_DBA2J_G0027942
 protein coding gene Chr4:31011361-31057055 (+)
FVB/NJ MGP_FVBNJ_G0027908
 protein coding gene Chr4:30426947-30474208 (+)
LP/J MGP_LPJ_G0028050
 protein coding gene Chr4:32289945-32335133 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027941
 protein coding gene Chr4:37109440-37157698 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028598
 protein coding gene Chr4:31870021-31916131 (+)
PWK/PhJ MGP_PWKPhJ_G0027000
 protein coding gene Chr4:31023259-31069000 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026829
 protein coding gene Chr4:31726688-31769948 (+)
WSB/EiJ MGP_WSBEiJ_G0027357
 protein coding gene Chr4:31867531-31913687 (+)



Homology
more
  • Human Ortholog
    RARS2, arginyl-tRNA synthetase 2, mitochondrial
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RARS2, arginyl-tRNA synthetase 2, mitochondrial
  • Synonyms
    ArgRS, DALRD2, PCH6, PRO1992, RARSL
  • Links
    NCBI Gene ID: 57038
    neXtProt AC: NX_Q5T160
    UniProt: Q5T160

  • Chr Location
    6q15; chr6:87513459-87590028 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human RARS2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    844
  • Tissues
    99
  • cDNA Data
    65
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028292 Ensembl Gene Model | MGI Sequence Detail 45211 C57BL/6J ±  kb
    transcript ENSMUST00000029968 Ensembl | MGI Sequence Detail 1868 Not Applicable  
    polypeptide ENSMUSP00000029968 Ensembl | MGI Sequence Detail 578 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000031350 probable arginine--tRNA ligase, mitochondrial
      (term hierarchy)
    • EC
      6.1.1.19
    • InterPro Domains
      IPR009080 Aminoacyl-tRNA synthetase, class Ia, anticodon-binding
      IPR001412 Aminoacyl-tRNA synthetase, class I, conserved site
      IPR001278 Arginine-tRNA ligase
      IPR035684 Arginyl-tRNA synthetase, catalytic core domain
      IPR036695 Arginyl tRNA synthetase N-terminal domain superfamily
      IPR008909 DALR anticodon binding
      IPR014729 Rossmann-like alpha/beta/alpha sandwich fold
    • GlyGen
      Q3U186 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 66
      cDNA 66

      Microarray probesets 3
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 2
      Gene Ontology 6
      Phenotypes 11
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory