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Trmt5 Gene Detail
Summary
  • Symbol
    Trmt5
  • Name
    TRM5 tRNA methyltransferase 5
  • Synonyms
    2610027O18Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923607
    NCBI Gene: 76357
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:73326785-73333484 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 12, 30.42 cM, cytoband D1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    286 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923607
protein coding gene Chr12:73315289-73333754 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019835
protein coding gene Chr12:73175877-73182175 (-)
A/J MGP_AJ_G0019793
protein coding gene Chr12:70439009-70445714 (-)
AKR/J MGP_AKRJ_G0019768
protein coding gene Chr12:72574295-72580596 (-)
BALB/cJ MGP_BALBcJ_G0019773
protein coding gene Chr12:70919513-70925804 (-)
C3H/HeJ MGP_C3HHeJ_G0019578
protein coding gene Chr12:73004624-73010927 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020225
protein coding gene Chr12:75453834-75460135 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017843
protein coding gene Chr12:67882760-67888589 (-)
CAST/EiJ MGP_CASTEiJ_G0019130
protein coding gene Chr12:67801996-67808277 (-)
CBA/J MGP_CBAJ_G0019548
protein coding gene Chr12:78329759-78336170 (-)
DBA/2J MGP_DBA2J_G0019664
protein coding gene Chr12:70334260-70340549 (-)
FVB/NJ MGP_FVBNJ_G0019651
protein coding gene Chr12:69182389-69188670 (-)
LP/J MGP_LPJ_G0019736
protein coding gene Chr12:73200200-73206460 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019690
protein coding gene Chr12:81463778-81470477 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020260
protein coding gene Chr12:72059615-72065918 (-)
PWK/PhJ MGP_PWKPhJ_G0018895
protein coding gene Chr12:64652147-64658939 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018690
protein coding gene Chr12:66482559-66488947 (-)
WSB/EiJ MGP_WSBEiJ_G0019181
protein coding gene Chr12:72649753-72656866 (-)



Homology
more
  • Human Ortholog
    TRMT5, tRNA methyltransferase 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRMT5, tRNA methyltransferase 5
  • Synonyms
    COXPD26, KIAA1393, PNSED, TRM5
  • Links
    NCBI Gene ID: 57570
    neXtProt AC: NX_Q32P41
    UniProt: Q32P41

  • Chr Location
    14q23.1; chr14:60971441-60981690 (-)  GRCh38

Human Diseases
more
  • Diseases
    1 with human TRMT5 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 2 genetic backgrounds
    1 images
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    12
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    3
  • Gene trapped
    5
  • Targeted
    3
  • Genomic Mutations
    1 involving Trmt5
  • Incidental Mutations
    APF , CvDC
  • Find Mice (IMSR)
Mice homozygous for a knock-out allele show complete embryonic lethality between implantation and somite formation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000034442 Ensembl Gene Model | MGI Sequence Detail 6700 C57BL/6J ±  kb
transcript ENSMUST00000116420 Ensembl | MGI Sequence Detail 2066 Not Applicable  
polypeptide ENSMUSP00000112121 Ensembl | MGI Sequence Detail 501 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000016682 tRNA (guanine-N(1)-)-methyltransferase
  • EC
  • InterPro Domains
    IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily
    IPR030382 SAM-dependent methyltransferase TRM5/TYW2-type
    IPR025792 tRNA (guanine(37)-N(1))-methyltransferase, eukaryotic
Molecular
Reagents
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  • All nucleic 33
    cDNA 33

    Microarray probesets 3
References
more
  • Summaries
    All 35
    Gene Ontology 6
    Phenotypes 11
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory