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Ip6k2 Gene Detail
Summary
  • Symbol
    Ip6k2
  • Name
    inositol hexaphosphate kinase 2
  • Synonyms
    1500005N04Rik, Ihpk2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923750
    NCBI Gene: 76500
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:108660995-108683536 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 59.63 cM, cytoband F2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    108 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923750
 protein coding gene Chr9:108660928-108683536 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035312
 protein coding gene Chr9:110774764-110797331 (+)
A/J MGP_AJ_G0035291
 protein coding gene Chr9:106707403-106729986 (+)
AKR/J MGP_AKRJ_G0035223
 protein coding gene Chr9:109386162-109408715 (+)
BALB/cJ MGP_BALBcJ_G0035285
 protein coding gene Chr9:106401569-106424340 (+)
C3H/HeJ MGP_C3HHeJ_G0034995
 protein coding gene Chr9:109785059-109807653 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035805
 protein coding gene Chr9:113793830-113818599 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032703
 protein coding gene Chr9:104118620-104141605 (+)
CAST/EiJ MGP_CASTEiJ_G0034306
 protein coding gene Chr9:109750482-109772915 (+)
CBA/J MGP_CBAJ_G0034963
 protein coding gene Chr9:117818376-117840895 (+)
DBA/2J MGP_DBA2J_G0035124
 protein coding gene Chr9:106162592-106185061 (+)
FVB/NJ MGP_FVBNJ_G0035072
 protein coding gene Chr9:104929361-104951964 (+)
LP/J MGP_LPJ_G0035200
 protein coding gene Chr9:110963577-110986031 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035111
 protein coding gene Chr9:119372934-119395397 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035826
 protein coding gene Chr9:109661662-109684248 (+)
PWK/PhJ MGP_PWKPhJ_G0034013
 protein coding gene Chr9:106493611-106516398 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033848
 protein coding gene Chr9:109724239-109747820 (+)
WSB/EiJ MGP_WSBEiJ_G0034427
 protein coding gene Chr9:109554219-109576756 (+)



Homology
more
  • Human Ortholog
    IP6K2, inositol hexakisphosphate kinase 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IP6K2, inositol hexakisphosphate kinase 2
  • Synonyms
    IHPK2, InsP6K2, PIUS
  • Links
    NCBI Gene ID: 51447
    neXtProt AC: NX_Q9UHH9
    UniProt: Q9UHH9

  • Chr Location
    3p21.31; chr3:48688003-48740353 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a null allele are resistant to radiation-induced mortality and show increased double-strand DNA break repair and incidence of induced aerodigestive tract carcinomas. Homozygotes for another null allele show increased B cell viability after radiation or neocarzinostatin treatment.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    40
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    819
  • Tissues
    105
  • cDNA Data
    11
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032599 Ensembl Gene Model | MGI Sequence Detail 22542 C57BL/6J ±  kb
    transcript ENSMUST00000085018 Ensembl | MGI Sequence Detail 1846 Not Applicable  
    polypeptide ENSMUSP00000082091 Ensembl | MGI Sequence Detail 448 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 12
      Primer pair 1

      Microarray probesets 10
    Other
    Accession IDs
    less
    MGI:2143285
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 4
      Gene Ontology 8
      Phenotypes 12
    • Earliest
      J:58528 Saiardi A, et al., Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinases. Curr Biol. 1999 Nov 18;9(22):1323-6
    • Latest
      J:347455 Ito M, et al., Inositol pyrophosphate profiling reveals regulatory roles of IP6K2-dependent enhanced IP(7) metabolism in the enteric nervous system. J Biol Chem. 2023 Jan 19;299(3):102928
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory