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Llcfc1 Gene Detail
Summary
  • Symbol
    Llcfc1
  • Name
    LLLL and CFNLAS motif containing 1
  • Synonyms
    1700034O15Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923856
    NCBI Gene: 76606
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:41661365-41662651 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 19.86 cM, cytoband B2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    103 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923856
 protein coding gene Chr6:41661321-41662651 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030633
 protein coding gene Chr6:40201463-40202749 (+)
A/J MGP_AJ_G0030606
 protein coding gene Chr6:38453709-38454995 (+)
AKR/J MGP_AKRJ_G0030531
 protein coding gene Chr6:39698508-39699794 (+)
BALB/cJ MGP_BALBcJ_G0030616
 protein coding gene Chr6:38659128-38660414 (+)
C3H/HeJ MGP_C3HHeJ_G0030329
 protein coding gene Chr6:39722123-39723409 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031070
 protein coding gene Chr6:41222524-41223810 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028277
 protein coding gene Chr6:36227761-36229028 (+)
CAST/EiJ MGP_CASTEiJ_G0029733
 protein coding gene Chr6:39530594-39531881 (+)
CBA/J MGP_CBAJ_G0030305
 protein coding gene Chr6:42921739-42923025 (+)
DBA/2J MGP_DBA2J_G0030449
 protein coding gene Chr6:38282319-38283605 (+)
FVB/NJ MGP_FVBNJ_G0030405
 protein coding gene Chr6:38004343-38005631 (+)
LP/J MGP_LPJ_G0030537
 protein coding gene Chr6:40203863-40205149 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030439
 protein coding gene Chr6:45154050-45155336 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031100
 protein coding gene Chr6:39669931-39671217 (+)
PWK/PhJ MGP_PWKPhJ_G0029445
 protein coding gene Chr6:37904048-37905336 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029282
 protein coding gene Chr6:39284535-39285820 (+)
WSB/EiJ MGP_WSBEiJ_G0029809
 protein coding gene Chr6:39582424-39583710 (+)



Homology
more
  • Human Ortholog
    LLCFC1, LLLL and CFNLAS motif containing 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LLCFC1, LLLL and CFNLAS motif containing 1
  • Synonyms
    C7orf34, ctm-1, SOF1
  • Links
    NCBI Gene ID: 135927
    neXtProt AC: NX_Q96L11
    UniProt: Q96L11

  • Chr Location
    7q34; chr7:142939343-142940868 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 3 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele show male infertility due to inability of spermatozoa to fuse with the oocyte membrane.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    3
  • GO References
    3
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    711
  • Tissues
    3
  • cDNA Data
    25
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029867 Ensembl Gene Model | MGI Sequence Detail 1287 C57BL/6J ±  kb
    transcript ENSMUST00000031900 Ensembl | MGI Sequence Detail 741 Not Applicable  
    polypeptide ENSMUSP00000031900 Ensembl | MGI Sequence Detail 108 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 25
      cDNA 25

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:5908146
    References
    more
    • Summaries
      All 31
      Developmental Gene Expression 1
      Gene Ontology 3
      Phenotypes 11
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:347210 Nishio S, et al., ZP2 cleavage blocks polyspermy by modulating the architecture of the egg coat. Cell. 2024 Mar 14;187(6):1440-1459.e24
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory